ICCAS OpenIR
Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods
Zhou, Qiuju1,2; Li, Lin1; Xiang, Junfeng1; Sun, Hongxia1; Tang, Yalin1
2009-02-01
Source PublicationBIOCHIMIE
ISSN0300-9084
Volume91Issue:2Pages:304-308
AbstractCurrently, there is a considerable interest in discovering G-quadruplex ligands. Plant-derived agents, because of their diversity in structure and bioactivity and low toxicity, may be a very diverse source of G-quadruplex ligands. However, up to now, the screening of G-quadruplex ligands from natural plant extract has not been reported. Herein, in order to develop a simple method for fast identifying G-quadruplex ligands from plant extract, we intended to substitute the spectral shift in the imino region (delta 10-12) in (1)H NMR spectra of G-quadruplex for in vitro bioassay to judge the existence/nonexistence of G-quadruplex ligand(s) in plant extract, and then couple G-quadruplex recognition with NMR based structure elucidation to identify the structure of the ligand(s) without the need of prior separation. In this paper, we successfully screened a G-quadruplex ligand from a simulated plant extract using this approach. This research work provides a promising tactic to find new leading compounds from nature plant extract. (C) 2008 Elsevier Masson SAS. All rights reserved.
DOI10.1016/j.biochi.2008.10.011
Indexed BySCI
Language英语
WOS IDWOS:000263813300017
PublisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65942
Collection中国科学院化学研究所
Corresponding AuthorTang, Yalin
Affiliation1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci,BNLMS, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Qiuju,Li, Lin,Xiang, Junfeng,et al. Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods[J]. BIOCHIMIE,2009,91(2):304-308.
APA Zhou, Qiuju,Li, Lin,Xiang, Junfeng,Sun, Hongxia,&Tang, Yalin.(2009).Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods.BIOCHIMIE,91(2),304-308.
MLA Zhou, Qiuju,et al."Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods".BIOCHIMIE 91.2(2009):304-308.
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