ICCAS OpenIR
A novel elsinochrome A derivative: a study of drug delivery and photodynamic activity
Zhang, Yang2; Xie, Jie2; Zhang, Luyong1; Li, Cong3; Chen, Hongxia1; Gu, Ying1; Zhao, Jingquan2
2009
Source PublicationPHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
ISSN1474-905X
Volume8Issue:12Pages:1676-1682
AbstractElsinochrome A (EA) possesses the highest singlet-oxygen quantum yield (0.98) amongst the perilenoquinoid pigments and may be suitable as a phototherapeutic drug. However, there have been virtually no studies into its medicinal applications. Based on the analysis of chemical derivatives of hypocrellins (the same family as EA), 5-(3-mercapto-1-propanesulfonic acid)-substituted elsinochrome A (MPEA) with an amphiphilicity was designed and synthesized by considering drug delivery and biological activity requirements. MPEA possesses a water solubility of 5.1 mg mL(-1), which is just sufficient to enable dissolution at a clinically acceptable concentration, while its partition coefficient (n-octanol/phosphate buffered saline) of 7 guarantees affinity to biological targets. MPEA could photogenerate semiquinone anion radicals and reactive oxygen species, especially singlet oxygen, at a yield of 0.73, which approaches that for hypocrellin B. Biological tests confirmed that the photodynamic activity of MPEA was as high as 60% of that of its parent EA, which is significantly higher than that of most other photosensitizers.
DOI10.1039/b9pp00046a
Indexed BySCI ; IC
Language英语
WOS IDWOS:000272142300005
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65900
Collection中国科学院化学研究所
Corresponding AuthorGu, Ying
Affiliation1.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Inst Chem, Key Lab Photochem, BNLMS, Beijing 100190, Peoples R China
3.Yunnan Univ, Dept Appl Chem, Kunming 650091, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yang,Xie, Jie,Zhang, Luyong,et al. A novel elsinochrome A derivative: a study of drug delivery and photodynamic activity[J]. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES,2009,8(12):1676-1682.
APA Zhang, Yang.,Xie, Jie.,Zhang, Luyong.,Li, Cong.,Chen, Hongxia.,...&Zhao, Jingquan.(2009).A novel elsinochrome A derivative: a study of drug delivery and photodynamic activity.PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES,8(12),1676-1682.
MLA Zhang, Yang,et al."A novel elsinochrome A derivative: a study of drug delivery and photodynamic activity".PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES 8.12(2009):1676-1682.
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