ICCAS OpenIR
Glucose-Sensitive Microcapsules from Glutaraldehyde Cross-Linked Hemoglobin and Glucose Oxidase
Qi, Wei1; Yan, Xuehai1,4; Juan, Li1,3; Cui, Yue1,4; Yang, Yang2; Li, Junbai1
2009-05-01
Source PublicationBIOMACROMOLECULES
ISSN1525-7797
Volume10Issue:5Pages:1212-1216
AbstractWe have fabricated the glucose-sensitive protein hollow microcapsules from hemoglobin (Hb) and glucose oxidase (GOx) via layer-by-layer technique with glutaraldehyde (GA) as a cross-linking agent. We demonstrated the coupled enzymatic reactions between Hb and GOx within capsules by means of CLSM. The real-time monitoring of the consumption of glucose may be useful for the design of a glucose sensor. Furthermore, to further study the effect of glucose on the capsules, we investigated the wall permeability of (Hb/GOx)(5) capsules. It was found that the glucose consumption could enhance the permeability of (Hb/GOx)(5) capsules. This is significant for the development of advanced drug delivery devices. Therefore, the fabricated Hb/GOx capsules may be a potential candidate for the creation of multifunctional devices.
DOI10.1021/bm801502r
Indexed BySCI
Language英语
WOS IDWOS:000265914200025
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:73[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65804
Collection中国科学院化学研究所
Corresponding AuthorLi, Junbai
Affiliation1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid & Interface Sci, Beijing Natl Lab Mol Sci,Int Joint Lab, Beijing 100190, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
3.NW Inst Nucl Technol, Xian 710024, Peoples R China
4.Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany
Recommended Citation
GB/T 7714
Qi, Wei,Yan, Xuehai,Juan, Li,et al. Glucose-Sensitive Microcapsules from Glutaraldehyde Cross-Linked Hemoglobin and Glucose Oxidase[J]. BIOMACROMOLECULES,2009,10(5):1212-1216.
APA Qi, Wei,Yan, Xuehai,Juan, Li,Cui, Yue,Yang, Yang,&Li, Junbai.(2009).Glucose-Sensitive Microcapsules from Glutaraldehyde Cross-Linked Hemoglobin and Glucose Oxidase.BIOMACROMOLECULES,10(5),1212-1216.
MLA Qi, Wei,et al."Glucose-Sensitive Microcapsules from Glutaraldehyde Cross-Linked Hemoglobin and Glucose Oxidase".BIOMACROMOLECULES 10.5(2009):1212-1216.
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