ICCAS OpenIR
Protein-responsive imprinted polymers with specific shrinking and rebinding
Chen, Zhiyong; Hua, Zhendong; Xu, Li; Huang, Yong; Zhao, Meiping; Li, Yuanzong
2008
Source PublicationJOURNAL OF MOLECULAR RECOGNITION
ISSN0952-3499
Volume21Issue:1Pages:71-77
AbstractStimuli-responsive protein imprinted polymers were obtained via a combination of molecular imprinting and reversible stimuli-responsive polymer using lysozyme or cytochrome c as template, N-isopropylacrylamide (NIPA) as major monomer, methacrylic acid (MAA) and acrylamide (AAm) as functional co-monomers, and N,N-methylenebisacrylamide (MBAAm) as crosslinker. The molecularly imprinted polymers (MIPs) can respond not only to external stimuli such as temperature and salt concentration, but also to the corresponding template protein with significant specific volume shrinking. This specific shrinking behavior was attributed to the synergistic effect of multiple-site weak interactions (electrostatic force, hydrogen bonding and hydrophobic interaction) and the cavity effect. The MIPs showed highly selective adsorption of template proteins with specific shrinking compared with the non-imprinted polymers. The results indicated that the MIPs seemed to change shape to accommodate the conformation of the template protein leading to the formation of a shape complementary cavity. Copyright (c) 2008 John Wiley & Sons, Ltd.
KeywordMolecularly Imprinted Polymer (Mip) Hydrogel Specific Shrinking Protein Recognition
DOI10.1002/jmr.870
Indexed BySCI
Language英语
WOS IDWOS:000253689800008
PublisherJOHN WILEY & SONS LTD
Citation statistics
Cited Times:58[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65636
Collection中国科学院化学研究所
Corresponding AuthorZhao, Meiping
AffiliationPeking Univ, Coll Chem & Mol Engn, Key Lab Bioorgan Chem & Mol Engn, BNLMS, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Chen, Zhiyong,Hua, Zhendong,Xu, Li,et al. Protein-responsive imprinted polymers with specific shrinking and rebinding[J]. JOURNAL OF MOLECULAR RECOGNITION,2008,21(1):71-77.
APA Chen, Zhiyong,Hua, Zhendong,Xu, Li,Huang, Yong,Zhao, Meiping,&Li, Yuanzong.(2008).Protein-responsive imprinted polymers with specific shrinking and rebinding.JOURNAL OF MOLECULAR RECOGNITION,21(1),71-77.
MLA Chen, Zhiyong,et al."Protein-responsive imprinted polymers with specific shrinking and rebinding".JOURNAL OF MOLECULAR RECOGNITION 21.1(2008):71-77.
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