ICCAS OpenIR
Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide)
He, Chaoliang1; Zhao, Changwen1; Guo, Xinhua2; Guo, Zhaojun1; Chen, Xuesi1; Zhuang, Xiuli1; Liu, Shuying2; Jing, Xiabin1
2008-06-15
Source PublicationJOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
ISSN0887-624X
Volume46Issue:12Pages:4140-4150
AbstractA series of novel temperature- and pH-responsive graft copolymers, poly(L-glutamic acid)-g-poly(N-isopropylacrylamide), were synthesized by coupling amino-semitelechelic poly(N-isopropylacrylamide) with N-hydroxysuccinimide-activated poly(L-glutamic acid). The graft copolymers and their precursors were characterized, by ESI-FTICR Mass Spectrum, intrinsic viscosity measurements and proton nuclear magnetic resonance ((1)H NMR). The phase-transition and aggregation behaviors of the graft copolymers in aqueous solutions were investigated by the turbidity measurements and dynamic laser scattering. The solution behavior of the copolymers showed dependence on both temperature and pH. The cloud point (CP) of the copolymer solution at pH 5.0-7.4 was slightly higher than that of the solution of the PNIPAM homopolymer because of the hydrophilic nature of the poly(glutamic acid) (PGA) backbone. The CP markedly decreased when the pH was lowered from 5 to 4.2, caused by the decrease in hydrophilicity of the PGA backbone. At a temperature above the lower critical solution temperature of the PNIPAM chain, the copolymers formed amphiphilic core-shell aggregates at pH 4.5-7.4 and the particle size was reduced with decreasing pH. In contrast, larger hydrophobic aggregates were formed at pH 4.2. (C) 2008 Wiley Periodicals, Inc.
KeywordBiodegradable Phase Behavior Poly(Glutamic Acid) Poly(N-isopropylacrylamide) Stimuli-sensitive Polymers
DOI10.1002/pola.22760
Indexed BySCI
Language英语
WOS IDWOS:000256643500026
PublisherWILEY-BLACKWELL
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65582
Collection中国科学院化学研究所
Corresponding AuthorChen, Xuesi
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, Green Chem & Process Lab, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
He, Chaoliang,Zhao, Changwen,Guo, Xinhua,et al. Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide)[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2008,46(12):4140-4150.
APA He, Chaoliang.,Zhao, Changwen.,Guo, Xinhua.,Guo, Zhaojun.,Chen, Xuesi.,...&Jing, Xiabin.(2008).Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide).JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,46(12),4140-4150.
MLA He, Chaoliang,et al."Novel temperature- and pH-responsive graft copolymers composed of poly(L-glutamic acid) and poly(N-isopropylacrylamide)".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 46.12(2008):4140-4150.
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