ICCAS OpenIR
Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles
Sun, Jing1,2; Shi, Quan1,2; Chen, Xuesi1; Guo, Jinshan1,2; Jing, Xiabin1
2008-06-05
Source PublicationMACROMOLECULAR CHEMISTRY AND PHYSICS
ISSN1022-1352
Volume209Issue:11Pages:1129-1136
AbstractThis report describes a facile route to prepare the vesicles and large compound micelles (LCMs) from a series of poly(epsilon-benzyloxycarbonyl L-lysine)-block-poly[diethylene glycol bis(3-amino propyl) ether]-block-poly(epsilon-benzyloxycarbonyl L-lySine) (PZLL-DGBE-PZLL) in their water solution, depending on molecular weight of the polypeptides. A pyrene probe is used to demonstrate the aggregate formation of PZLL-DGBE-PZLL in solution, and also to measure their critical micelle concentration as a function of molecular weight of the polymer. Transmission electron microscopy, atomic force microscopy, dynamic light scattering and confocal laser scanning microscopy are used to observe their aggregate morphologies. Rhodamine B is used as a fluorescent probe to confirm the structure of large compound micelles composed of many reverse micelles with aqueous cores. These polypeptides are prepared by ring-opening polymerization of a-amino acid N-carboxyanhydrides with a small molecule as the initiator. Their structures are confirmed by NMR and SEC-MALLS. These vesicles and large compound micelles are extremely expected to be used in drug delivery.
KeywordLarge Compound Micelles N-carboxyanhydride (Nca) Polypeptides Self-assembly Vesicles
DOI10.1002/macp.200800018
Indexed BySCI
Language英语
WOS IDWOS:000256825900005
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65564
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Sun, Jing,Shi, Quan,Chen, Xuesi,et al. Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles[J]. MACROMOLECULAR CHEMISTRY AND PHYSICS,2008,209(11):1129-1136.
APA Sun, Jing,Shi, Quan,Chen, Xuesi,Guo, Jinshan,&Jing, Xiabin.(2008).Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles.MACROMOLECULAR CHEMISTRY AND PHYSICS,209(11),1129-1136.
MLA Sun, Jing,et al."Self-assembly of a hydrophobic polypeptide containing a short hydrophilic middle segment: Vesicles to large compound micelles".MACROMOLECULAR CHEMISTRY AND PHYSICS 209.11(2008):1129-1136.
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