Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)
Zhu, Jiadan1; Ji, Zhiqiang1; Wang, Jing1; Sun, Ronghua1; Zhang, Xiang1; Gao, Yang1; Sun, Hongfang1; Liu, Yuanfang1,3; Wang, Zheng2; Li, Aidong2; Ma, Jie2; Wang, Tiancheng4; Jia, Guang4; Gu, Yiqun5
Source PublicationSMALL
AbstractThe tumor-inhibitory effect of C-60(OH)(x) was tested on the murine H22 hepatocarcinoma model. Doses of 0.2 and 1.0 mg kg(-1) body weight both showed significant antitumor activity with tumor inhibition rates of 31.9 and 38.4%, respectively, when mice were treated for 17 consecutive days. The damnification of liver was prominently reduced. Furthermore, histological examination indicated that an envelope of fibroblasts and lymphocytes was formed surrounding tumor tissues in the C-60(OH)(x)-treated group, which inhibited the infiltration of tumor to the neighboring normal skeleton muscle tissues. To understand the antitumor mechanism, the immunomodulatory activity of C-60(OH)(x) was investigated. The results indicate that C-60(OH)(x) enhances the phagocytosis of peritoneal macrophages and elevates the activity of arginase and acid phosphatase in vivo. The tumor necrosis factor alpha production of C-60(OH)(x)-treated macrophages also increases in vitro. These results suggest that C-60(OH)(x) can enhance the innate immunity of tumor-bearing mice, and therefore inhibits growth of the tumor.
KeywordAntitumor Agents Fullerol Immunology Macrophages Toxicology
Indexed BySCI
WOS IDWOS:000258566400026
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Cited Times:70[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorSun, Hongfang
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Peking Union Med Coll, Chinese Acad Med Sci, Inst Canc, State Key Lab Mol Oncol, Beijing 100021, Peoples R China
3.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
4.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100083, Peoples R China
5.HaiDian Maternal & Child Hlth Hosp, Dept Pathol, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Jiadan,Ji, Zhiqiang,Wang, Jing,et al. Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)[J]. SMALL,2008,4(8):1168-1175.
APA Zhu, Jiadan.,Ji, Zhiqiang.,Wang, Jing.,Sun, Ronghua.,Zhang, Xiang.,...&Gu, Yiqun.(2008).Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x).SMALL,4(8),1168-1175.
MLA Zhu, Jiadan,et al."Tumor-inhibitory effect and immunomodulatory activity of fullerol C-60(OH)(x)".SMALL 4.8(2008):1168-1175.
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