ICCAS OpenIR
Grafting BSA onto poly[(L-lactide)-co-carbonate] microspheres by click chemistry
Han, Yadong1,2; Shi, Quan1,2; Hu, Junli1,2; Du, Qing1,2; Chen, Xuesi1; Jing, Xiabin1
2008-07-07
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume8Issue:7Pages:638-644
AbstractModel protein bovine serum albumin (BSA) was covalently grafted onto poly[(L-lactide)co-carbonate] microsphere surfaces by "click chemistry." The grafting was confirmed by confocal laser scanning microscopy and X-ray photoelectron spectroscopy. The maximum amount of surface-grafted BSA was 45 mg.g(-1). The secondary structure of the grafted BSA was analyzed by FTIR and the results demonstrated that the grafting did not affect protein structure. This strategy can also be used on microspheres prepared from poly(L-lactide)/poly[(L-lactide)-co-carbonate] blend materials.
KeywordBiodegradable Biopolymers Click Polycarborates Proteins
DOI10.1002/mabi.200700306
Indexed BySCI
Language英语
WOS IDWOS:000257817300005
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65256
Collection中国科学院化学研究所
Corresponding AuthorChen, Xuesi
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Han, Yadong,Shi, Quan,Hu, Junli,et al. Grafting BSA onto poly[(L-lactide)-co-carbonate] microspheres by click chemistry[J]. MACROMOLECULAR BIOSCIENCE,2008,8(7):638-644.
APA Han, Yadong,Shi, Quan,Hu, Junli,Du, Qing,Chen, Xuesi,&Jing, Xiabin.(2008).Grafting BSA onto poly[(L-lactide)-co-carbonate] microspheres by click chemistry.MACROMOLECULAR BIOSCIENCE,8(7),638-644.
MLA Han, Yadong,et al."Grafting BSA onto poly[(L-lactide)-co-carbonate] microspheres by click chemistry".MACROMOLECULAR BIOSCIENCE 8.7(2008):638-644.
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