ICCAS OpenIR
Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin
Zhou, Qiuju1,2; Xiang, Junfeng1; Tang, Yalin1; Liao, Jiangpeng2,3; Yu, Chuyi; Du, Hongyan1,2; Yang, Qianfan1,2; Xu, Guangzhi1
2008-09-01
Source PublicationPESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
ISSN0048-3575
Volume92Issue:1Pages:43-47
AbstractThe interaction of a novel pesticide, NMD (spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5'-(2-nitromethylene-1,3-diazacyclohexane)]), with bovine serum albumin (BSA) has been investigated by using absorption, fluorescence, and circular dichroism (CD) spectroscopy methods. Quenching of the fluorescence of BSA has been observed in the presence of NMD. The binding parameters were determined using Stern-Volmer equation. From the thermodynamic parameters calculated according to the van't Hoff equation, the enthalpy change Delta H, and entropy change AS were found to be -2.71 kJ mol(-1) and 82.56 J mol(-1) K-1, respectively. These values suggested that, apart from an initial hydrophobic association, the complex is held together by van der Waals interactions and hydrogen bonding. These results provided a quantitative understanding of the binding of NMD to BSA, which is important in understanding its toxicity in vertebrates. (C) 2008 Elsevier Inc. All rights reserved.
Keyword2-nitromethylene-1-3-diazacycloalkanes Bovine Serum Albumin Circular Dichroism Fluorescence Quenching
DOI10.1016/j.pestbp.2008.06.002
Indexed BySCI
Language英语
WOS IDWOS:000258560900008
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65232
Collection中国科学院化学研究所
Corresponding AuthorTang, Yalin
Affiliation1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci,BNLMS, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Chem, Lab Mol Recognit & Select Synth, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Qiuju,Xiang, Junfeng,Tang, Yalin,et al. Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin[J]. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,2008,92(1):43-47.
APA Zhou, Qiuju.,Xiang, Junfeng.,Tang, Yalin.,Liao, Jiangpeng.,Yu, Chuyi.,...&Xu, Guangzhi.(2008).Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin.PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,92(1),43-47.
MLA Zhou, Qiuju,et al."Interaction of spiro[(2R,3R,4S)-4-benzyloxy-2,3-iso-propylidenedioxy-1-oxacyclopentane-5,5 '-(2-nitromethylene-1,3-diazacyclohexane)] with bovine serum albumin".PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 92.1(2008):43-47.
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