ICCAS OpenIR
Spectroscopic investigation on the interaction of a cyarline dye with serum albumins
Zhang Ya-Zhou1,2; Yang Qian-Fan1,2; Du Hong-Yan1,2; Tang Ya-Lin1; Xu Guang-Zhi1; Yan Wen-Peng3
2008-02-01
Source PublicationCHINESE JOURNAL OF CHEMISTRY
ISSN1001-604X
Volume26Issue:2Pages:397-401
AbstractThe interactions of a cyanine dye with human serum albumin (HSA) and bovine serum albumin (BSA) have been investigated by using absorption and fluorescence spectra. Absorption spectral studies show that binding to the serum albumins leads to a bathochromic shift of the monomer band together with a notable intensity change. Furthermore, the number of binding sites (n) was identified by the absorption spectra. There is a constant enhancement of fluorescence quantum yield when the cyanine dye complexes with HSA or BSA. The apparent binding constant (K(a)) and the free energy changes (Delta G) were obtained by analysis of fluorescence data of the cyanine dye in the absence and presence of HSA and BSA. Compared to BSA, HSA associates with the dye in a stronger way.
KeywordHuman Serum Albumin Bovine Serum Albumin Fluorescent Probe Cyanine Dye
Indexed BySCI ; IC
Language英语
WOS IDWOS:000253710900030
PublisherWILEY-BLACKWELL
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/65164
Collection中国科学院化学研究所
Corresponding AuthorZhang Ya-Zhou
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China
2.Grad Univ Chinese Acad Sci, Beijing 100080, Peoples R China
3.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhang Ya-Zhou,Yang Qian-Fan,Du Hong-Yan,et al. Spectroscopic investigation on the interaction of a cyarline dye with serum albumins[J]. CHINESE JOURNAL OF CHEMISTRY,2008,26(2):397-401.
APA Zhang Ya-Zhou,Yang Qian-Fan,Du Hong-Yan,Tang Ya-Lin,Xu Guang-Zhi,&Yan Wen-Peng.(2008).Spectroscopic investigation on the interaction of a cyarline dye with serum albumins.CHINESE JOURNAL OF CHEMISTRY,26(2),397-401.
MLA Zhang Ya-Zhou,et al."Spectroscopic investigation on the interaction of a cyarline dye with serum albumins".CHINESE JOURNAL OF CHEMISTRY 26.2(2008):397-401.
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