ICCAS OpenIR
Aliphatic Poly(ester-carbonate)s Bearing Amino Groups and Its RGD Peptide Grafting
Hu, Xuli1,2; Chen, Xuesi1; Xie, Zhigang1,2; Cheng, Haibo1,2; Jing, Xiabin1
2008-11-01
Source PublicationJOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
ISSN0887-624X
Volume46Issue:21Pages:7022-7032
AbstractThis article deals with (1) synthesis of novel cyclic carbonate monomer (2-oxo [1,3]dioxan-5-yl)carbamic acid benzyl ester (CAB) containing protected amino groups; (2) ring-opening copolymerization of the cyclic monomer with L-lactide (LA) to provide novel degradable poly(ester-carbonate)s with functional groups; (3) removal of the protective benzyloxycarbonyl (Cbz) groups by catalytic hydrogenation to afford the corresponding poly(ester-co-carbonate)s with free amino groups; (4) grafting of oligopeptide Gly-Arg-Gly-Asp-Ser-Tyr (GRGDSY, abbreviated as RGD) onto the copolymer pendant amino groups in the presence of 1,1'-carbonyldiimidazole (CDI). The structures of P(LA-co-CA/RGD) and its precursor were confirmed by H-1 NMR analysis. Cell experiments showed that P(LA-co-CA/RGD) had improved adhesion and proliferation behavior. Therefore, the novel RGD-grafted block copolymer is promising for cell or tissue engineering applications. (C) 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7022-7032, 2008
KeywordAmino Groups Biodegradable Functionalization Of Polymers Polycarbonates Rgd
DOI10.1002/pola.23008
Indexed BySCI
Language英语
WOS IDWOS:000260587100016
PublisherJOHN WILEY & SONS INC
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64660
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xuli,Chen, Xuesi,Xie, Zhigang,et al. Aliphatic Poly(ester-carbonate)s Bearing Amino Groups and Its RGD Peptide Grafting[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2008,46(21):7022-7032.
APA Hu, Xuli,Chen, Xuesi,Xie, Zhigang,Cheng, Haibo,&Jing, Xiabin.(2008).Aliphatic Poly(ester-carbonate)s Bearing Amino Groups and Its RGD Peptide Grafting.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,46(21),7022-7032.
MLA Hu, Xuli,et al."Aliphatic Poly(ester-carbonate)s Bearing Amino Groups and Its RGD Peptide Grafting".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 46.21(2008):7022-7032.
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