Knowledge Management System Of Institute of Chemistry，CAS
| Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water | |
| Zhao, Changwen1,2; Zhuang, Xiuli1; He, Chaoliang1; Chen, Xuesi1; Jing, Xiabin1 | |
| 2008-11-19 | |
| Source Publication | MACROMOLECULAR RAPID COMMUNICATIONS
 |
| ISSN | 1022-1336 |
| Volume | 29Issue:22Pages:1810-1816 |
| Abstract | A series of novel temperature and pH responsive block copolymers composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(L-lysine) (PLL) were synthesized. The effect of pH and the length of PLL on the lower critical solution temperature (LCST) of PNIPAM, and the self-assembly of these PLL-based copolymers induced by temperature and pH changes were investigated by the cloud point method, dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM). These PNIPAM-b-PLL copolymers can self-assemble into micelle-like aggregates with PNIPAM as the hydrophobic block at acidic pH and high temperatures; and at alkaline pH and low hey can self-assemble into temperatures, particles with PLL as the hydrophobic block. The copolymers may have potential applications in biotechnological and biomedical areas as drug release carriers. |
| Keyword | Hydrophilic Polymers Ph Responsive Polypeptide Self-assembly Temperature Responsive |
| DOI | 10.1002/marc.200800494 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000261544700005 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/64510 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Zhuang, Xiuli |
| Affiliation | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,et al. Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2008,29(22):1810-1816. |
| APA | Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,Chen, Xuesi,&Jing, Xiabin.(2008).Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water.MACROMOLECULAR RAPID COMMUNICATIONS,29(22),1810-1816. |
| MLA | Zhao, Changwen,et al."Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water".MACROMOLECULAR RAPID COMMUNICATIONS 29.22(2008):1810-1816. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment