ICCAS OpenIR
Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water
Zhao, Changwen1,2; Zhuang, Xiuli1; He, Chaoliang1; Chen, Xuesi1; Jing, Xiabin1
2008-11-19
Source PublicationMACROMOLECULAR RAPID COMMUNICATIONS
ISSN1022-1336
Volume29Issue:22Pages:1810-1816
AbstractA series of novel temperature and pH responsive block copolymers composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(L-lysine) (PLL) were synthesized. The effect of pH and the length of PLL on the lower critical solution temperature (LCST) of PNIPAM, and the self-assembly of these PLL-based copolymers induced by temperature and pH changes were investigated by the cloud point method, dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM). These PNIPAM-b-PLL copolymers can self-assemble into micelle-like aggregates with PNIPAM as the hydrophobic block at acidic pH and high temperatures; and at alkaline pH and low hey can self-assemble into temperatures, particles with PLL as the hydrophobic block. The copolymers may have potential applications in biotechnological and biomedical areas as drug release carriers.
KeywordHydrophilic Polymers Ph Responsive Polypeptide Self-assembly Temperature Responsive
DOI10.1002/marc.200800494
Indexed BySCI
Language英语
WOS IDWOS:000261544700005
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64510
Collection中国科学院化学研究所
Corresponding AuthorZhuang, Xiuli
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,et al. Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water[J]. MACROMOLECULAR RAPID COMMUNICATIONS,2008,29(22):1810-1816.
APA Zhao, Changwen,Zhuang, Xiuli,He, Chaoliang,Chen, Xuesi,&Jing, Xiabin.(2008).Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water.MACROMOLECULAR RAPID COMMUNICATIONS,29(22),1810-1816.
MLA Zhao, Changwen,et al."Synthesis of Novel Thermo- and pH-Responsive Poly(L-lysine)-Based Copolymer and its Micellization in Water".MACROMOLECULAR RAPID COMMUNICATIONS 29.22(2008):1810-1816.
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