ICCAS OpenIR
Inhibition of acrylamide toxicity in mice by three dietary constituents
Xie, Qunying1; Liu, Ye1; Sun, Hongfang1; Liu, Yuanfang1; Ding, Xingfang2; Fu, Dongpo2; Liu, Kexin2; Du, Xianmei3; Jia, Guang3
2008-08-13
Source PublicationJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN0021-8561
Volume56Issue:15Pages:6054-6060
Abstractinhibitory effects of three dietary constituents, tea polyphenols, resveratrol, and diallyl trisulfide, on acrylamide-biomacromolecule (liver DNA, prolamine, and hemoglobin) adduct formation at human exposure level were studied by accelerator mass spectrometry. The results demonstrated that the three dietary constituents all significantly inhibited the formation of acrylamide adducts with liver DNA, whereas tea polyphenols and diallyl trisulfide reduced prolamine and hemoglobin adducts, respectively. Further biochemical studies showed that acrylamide could significantly inactivate creatine kinase and glutathione S-transferase and deplete glutathione. When the inhibitors were cotreated with acrylamide, all of them could effectively recover the activities of creatine kinase. In addition, tea polyphenols and diallyl trisulfide could increase glutathione S-transferase activity remarkably. On the basis of these results, mechanisms of the effects are discussed. This study might provide a beneficial guide to people's diet for the purpose of reducing the harmful effect of acrylamide.
KeywordAcrylamide-biomacromolecule Adducts Tea Polyphenol Resveratrol Diallyl Trisulfide Inhibition Creatine Kinase Glutathione S-transferase Accelerator Mass Spectrometry
DOI10.1021/jf0730542
Indexed BySCI
Language英语
WOS IDWOS:000258270300012
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64410
Collection中国科学院化学研究所
Corresponding AuthorSun, Hongfang
Affiliation1.Peking Univ, State Key Lab Nucl Phys & Technol, Coll Chem & Mol Engn, Dept Biol Chem,Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Peking Univ, Sch Phys, Inst Heavy Ion Phys, Beijing 100871, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Xie, Qunying,Liu, Ye,Sun, Hongfang,et al. Inhibition of acrylamide toxicity in mice by three dietary constituents[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2008,56(15):6054-6060.
APA Xie, Qunying.,Liu, Ye.,Sun, Hongfang.,Liu, Yuanfang.,Ding, Xingfang.,...&Jia, Guang.(2008).Inhibition of acrylamide toxicity in mice by three dietary constituents.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,56(15),6054-6060.
MLA Xie, Qunying,et al."Inhibition of acrylamide toxicity in mice by three dietary constituents".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 56.15(2008):6054-6060.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xie, Qunying]'s Articles
[Liu, Ye]'s Articles
[Sun, Hongfang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xie, Qunying]'s Articles
[Liu, Ye]'s Articles
[Sun, Hongfang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xie, Qunying]'s Articles
[Liu, Ye]'s Articles
[Sun, Hongfang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.