ICCAS OpenIR
Synthesis of biodegradable and electroactive multiblock polylactide and aniline pentamer copolymer for tissue engineering applications
Huang, Lihong1,2; Zhuang, Xiuli1; Hu, Jun2; Lang, Le1; Zhang, Peibiao1; Wang, Yu1; Chen, Xuesi1; Wei, Yen3; Jing, Xiabin1
2008-03-01
Source PublicationBIOMACROMOLECULES
ISSN1525-7797
Volume9Issue:3Pages:850-858
AbstractTo obtain one biodegradable and electroactive polymer as the scaffold for tissue engineering, the multiblock copolymer PLAAP was designed and synthesized with the condensation polymerization of hydroxyl-capped poly(L-lactide) (PLA) and carboxyl-capped aniline pentamer (AP). The PLAAP copolymer exhibited excellent electroactivity, solubility, and biodegradability. At the same time, as one scaffold material, PLAAP copolymer possesses certain mechanical properties with the tensile strength of 3 MPa, tensile Young 's modulus of 32 MPa, and breaking elongation rate of 95%. We systematically studied the compatibility of PLAAP copolymer in vitro and proved that the electroactive PLAAP copolymer was innocuous, biocompatible, and helpful for the adhesion and proliferation of rat C6 cells. Moreover, the PLAAP copolymer stimulated by electrical signals was demonstrated as accelerating the differentiation of rat neuronal pheochromocytoma PC-12 cells. This biodegradable and electroactive PLAAP copolymer thus possessed the properties in favor of the long-time application in vivo as nerve repair scaffold materials in tissue engineering.
DOI10.1021/bm7011828
Indexed BySCI
Language英语
WOS IDWOS:000253926400014
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:142[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64354
Collection中国科学院化学研究所
Corresponding AuthorChen, Xuesi
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Drexel Univ, Sch Biomed Engn, Philadelphia, PA 19104 USA
Recommended Citation
GB/T 7714
Huang, Lihong,Zhuang, Xiuli,Hu, Jun,et al. Synthesis of biodegradable and electroactive multiblock polylactide and aniline pentamer copolymer for tissue engineering applications[J]. BIOMACROMOLECULES,2008,9(3):850-858.
APA Huang, Lihong.,Zhuang, Xiuli.,Hu, Jun.,Lang, Le.,Zhang, Peibiao.,...&Jing, Xiabin.(2008).Synthesis of biodegradable and electroactive multiblock polylactide and aniline pentamer copolymer for tissue engineering applications.BIOMACROMOLECULES,9(3),850-858.
MLA Huang, Lihong,et al."Synthesis of biodegradable and electroactive multiblock polylactide and aniline pentamer copolymer for tissue engineering applications".BIOMACROMOLECULES 9.3(2008):850-858.
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