ICCAS OpenIR
A weak cation monolithic column for enrichment and determination of ranitidine hydrochloride in human urine
Zhu Tao1,2; Yang Geng-Liang1,2,3; Jiang Ming-Ming1,2; Cao Wei-Min1,2
2008-07-01
Source PublicationCHINESE JOURNAL OF ANALYTICAL CHEMISTRY
ISSN0253-3820
Volume36Issue:7Pages:895-899
AbstractA weak cation exchange monolithic column was prepared in stainless steel column tubule, which was used for analysis and determination of ranitidine hydrochloride as solid phase extraction (SPE) material in urine samples. With the column switch technique, online cleaning up and screening of human urine sample was executed under the condition of 2.5 mmol/L K2HPO4 solutions. Chromatographic operation was performed by reversed-phase HPLC on a C-18 column with 1.0 mL/min flow ratio and ultraviolet detection at 320 nm, using an eluting solution consisting of methanol-2. 5 mmol/L K2HPO4 (2: 1, V/V). Results showed that there was a good linear relationship between the response and the concentration of ranitidine hydrochloride within the range of 0.05 - 5.0 mg/L (r = 0. 9994, n = 7). The absolutely recovery rate was from 75.0% to 85.0% and the detection limit was 0. 01 mg/L. The inter-day RSD and intra-day RSD were less than 5%. This method was suitable for the determination of Ranitidine hydrochloride in human urine, which had avoided tedious pretreatment and provided a fast, economic, repeated and effective method for assaying trace drugs in biologic samples.
KeywordWeak Cation Monolithic Column On-line Solid Phase Extraction Column Switch Urine Sample Ranitidine Hydrochloride
Indexed BySCI
Language英语
WOS IDWOS:000258939700006
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64346
Collection中国科学院化学研究所
Corresponding AuthorYang Geng-Liang
Affiliation1.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China
2.Hebei Prov Key Lab Med Qual Res, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhu Tao,Yang Geng-Liang,Jiang Ming-Ming,et al. A weak cation monolithic column for enrichment and determination of ranitidine hydrochloride in human urine[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2008,36(7):895-899.
APA Zhu Tao,Yang Geng-Liang,Jiang Ming-Ming,&Cao Wei-Min.(2008).A weak cation monolithic column for enrichment and determination of ranitidine hydrochloride in human urine.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,36(7),895-899.
MLA Zhu Tao,et al."A weak cation monolithic column for enrichment and determination of ranitidine hydrochloride in human urine".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 36.7(2008):895-899.
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