ICCAS OpenIR
Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution
Ding Hui-Ying1; Zhang Yang2; Gu Ying1; Zhao Jing-Quan2
2008-03-01
Source PublicationCHINESE JOURNAL OF CHEMISTRY
ISSN1001-604X
Volume26Issue:3Pages:510-515
AbstractPhotodynamic therapy (PDT) is a new methodology to utilize jointly a photosensitizer and light to destroy the target tissues of diseases via some photochemical reactions. On the other hand, the photosensitizer molecules may also be photo-bleached during PDT, furthermore, their interaction with biomolecules and the photobleaching properties in blood vessels are critical to treatments of microvascular diseases. In consideration of these, the photobleaching processes of HB and its analogue THB in plasma solutions were investigated in the current work. It was observed that the photobleaching was predominately mediated by singlet oxygen reactions in well-oxygenated aqueous solution in the presence of plasma substrate which not only greatly enhanced the photobleaching rate but also led to different photoproducts due to distinctly different reaction mechanisms. The relative photobleaching mechanisms were proposed based on the structural information and the redox potentials of the photosensitizers.
KeywordHypocrellin Singlet Oxygen Photobleaching Photodynamic Therapy
Indexed BySCI
Language英语
WOS IDWOS:000254466500019
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64328
Collection中国科学院化学研究所
Corresponding AuthorDing Hui-Ying
Affiliation1.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China
2.Chinese Acad Sci, Ctr Mol Sci, Inst Chem, Key Lab Photochem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Ding Hui-Ying,Zhang Yang,Gu Ying,et al. Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution[J]. CHINESE JOURNAL OF CHEMISTRY,2008,26(3):510-515.
APA Ding Hui-Ying,Zhang Yang,Gu Ying,&Zhao Jing-Quan.(2008).Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution.CHINESE JOURNAL OF CHEMISTRY,26(3),510-515.
MLA Ding Hui-Ying,et al."Photobleaching of hypocrellin B and 2-taurine substituted hypocrellin B in plasma solution".CHINESE JOURNAL OF CHEMISTRY 26.3(2008):510-515.
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