ICCAS OpenIR
Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent
Shu, Chun-Ying1; Wang, Chun-Ru1; Zhang, Jian-Fei2; Gibson, Harry W.2; Dorn, Harry C.2; Corwin, Frank D.3; Fatouros, Panos P.3; Dennis, T. John S.4
2008-03-25
Source PublicationCHEMISTRY OF MATERIALS
ISSN0897-4756
Volume20Issue:6Pages:2106-2109
AbstractA new magnetic resonance imaging contrast agent containing organophosphonate functional groups was synthesized in high yield by a simple synthesis procedure. This molecule exhibits much higher longitudinal water proton relaxivity (37.0 mM(-1) s(-1)) than commercial Omniscan (Gd-DTPA BMA, 5.7 mM(-1) s(-1)) at 0.35 T. Notably, the relaxivity is larger than that of carboxylated Gd@C-82 (16.0 mM(-1) s(-1)) under the same conditions, indicating that the functional groups have an important role on the image contrast enhancement. In addition, the introduction of phosphonate substituents may provide bone-targeting MRI contrast agents.
DOI10.1021/cm7023982
Indexed BySCI
Language英语
WOS IDWOS:000254128800012
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:48[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64310
Collection中国科学院化学研究所
Corresponding AuthorWang, Chun-Ru
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24060 USA
3.Virginia Commonwealth Univ, Dept Radiol, Richmond, VA 23298 USA
4.Queen Mary Univ London, Ctr Mat Res, London E1 4NS, England
Recommended Citation
GB/T 7714
Shu, Chun-Ying,Wang, Chun-Ru,Zhang, Jian-Fei,et al. Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent[J]. CHEMISTRY OF MATERIALS,2008,20(6):2106-2109.
APA Shu, Chun-Ying.,Wang, Chun-Ru.,Zhang, Jian-Fei.,Gibson, Harry W..,Dorn, Harry C..,...&Dennis, T. John S..(2008).Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent.CHEMISTRY OF MATERIALS,20(6),2106-2109.
MLA Shu, Chun-Ying,et al."Organophosphonate functionalized Gd@C-82 as a magnetic resonance imaging contrast agent".CHEMISTRY OF MATERIALS 20.6(2008):2106-2109.
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