ICCAS OpenIR
A generally adoptable radiotracing method for tracking carbon nanotubes in animals
Deng, Xiaoyong1,2; Yang, Shengtao1; Nie, Haiyu1; Wang, Haifang1; Liu, Yuanfang1,2
2008-02-20
Source PublicationNANOTECHNOLOGY
ISSN0957-4484
Volume19Issue:7
AbstractCarbon nanotube (CNT) mediated drug delivery systems have currently aroused a great deal of interest. Such delivery systems for drugs, proteins and genes have been preliminarily studied using cellular and animal models. For the further study of the pharmacokinetics and related biological behaviours of CNTs in vivo, a fast and convenient tracing method is particularly demanded. In this paper, we developed a generally adoptable tracing method for the biodistribution study of functionalized CNTs in vivo. Taurine covalently functionalized multi-walled carbon nanotubes (tau-MWNTs) and Tween-80 wrapped MWNTs (Tween-MWNTs) were labelled with (125)I, and then their distribution in mice was determined. It is interesting that Tween-80 can reduce the RES uptake of MWNTs remarkably. The resulting distribution of (125)I-tau-MWNTs was very consistent with that using (14)C-taurine-MWNTs as the CNTs tracer, which means the easy (125)I labelling method is reliable and effective.
DOI10.1088/0957-4484/19/7/075101
Indexed BySCI
Language英语
WOS IDWOS:000252967300001
PublisherIOP PUBLISHING LTD
Citation statistics
Cited Times:51[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64104
Collection中国科学院化学研究所
Corresponding AuthorWang, Haifang
Affiliation1.Peking Univ, Dept Biol Chem, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
Recommended Citation
GB/T 7714
Deng, Xiaoyong,Yang, Shengtao,Nie, Haiyu,et al. A generally adoptable radiotracing method for tracking carbon nanotubes in animals[J]. NANOTECHNOLOGY,2008,19(7).
APA Deng, Xiaoyong,Yang, Shengtao,Nie, Haiyu,Wang, Haifang,&Liu, Yuanfang.(2008).A generally adoptable radiotracing method for tracking carbon nanotubes in animals.NANOTECHNOLOGY,19(7).
MLA Deng, Xiaoyong,et al."A generally adoptable radiotracing method for tracking carbon nanotubes in animals".NANOTECHNOLOGY 19.7(2008).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Deng, Xiaoyong]'s Articles
[Yang, Shengtao]'s Articles
[Nie, Haiyu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Deng, Xiaoyong]'s Articles
[Yang, Shengtao]'s Articles
[Nie, Haiyu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Deng, Xiaoyong]'s Articles
[Yang, Shengtao]'s Articles
[Nie, Haiyu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.