ICCAS OpenIR
The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning
Xu, Xiuling4; Chen, Xuesi; Ma, Ping'an2; Wang, Xinri3; Jing, Xiabin1
2008-09-01
Source PublicationEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
ISSN0939-6411
Volume70Issue:1Pages:165-170
AbstractThe release behavior of a water-soluble small molecule drug from the drug-loaded nanofibers prepared by emulsion-electrospinning was investigated. Doxorubicin hydrochloride (Dox), a water-soluble anticancer agent, was used as the model drug. The laser scanning confocal microscopic images indicated that the drug was well incorporated into amphiphilic poly(ethylene glycol)-poly(L-lactic acid) (PEG-PLA) diblock copolymer nanofibers, forming "core-sheath" structured drug-loaded nanofibers. The drug release behavior of this drug-loaded system showed a three-stage diffusion-controlled mechanism, in which the release rate of the first stage was slower than that of the second stage, but both obeyed Fick's second law. Based on these results, it is concluded that the Dox-loaded fibers prepared by emulsion-electrospinning represent a reservoir-type delivery system in which the Dox release rate decreases with the increasing Dox content in the fibers. (c) 2008 Elsevier B.V. All rights reserved.
KeywordEmulsion Electrospinning Nanofiber Drug Delivery Diffusion
DOI10.1016/j.ejpb.2008.03.010
Indexed BySCI
Language英语
WOS IDWOS:000259742600018
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:140[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/64100
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.NE Normal Univ, Sch Life Sci, Changchun, Peoples R China
3.Jilin Univ, Minist Educ, Key Lab Zoonosis, Changchun 130023, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Xu, Xiuling,Chen, Xuesi,Ma, Ping'an,et al. The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2008,70(1):165-170.
APA Xu, Xiuling,Chen, Xuesi,Ma, Ping'an,Wang, Xinri,&Jing, Xiabin.(2008).The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,70(1),165-170.
MLA Xu, Xiuling,et al."The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 70.1(2008):165-170.
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