ICCAS OpenIR
Water-Soluble Dendritic-Conjugated Polyfluorenes: Synthesis, Characterization, and Interactions with DNA
Yu, Minghui; Liu, Libing; Wang, Shu
2008-11-15
Source PublicationJOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
ISSN0887-624X
Volume46Issue:22Pages:7462-7472
AbstractThree generation of Boc-protected dendritic-conjugated polyfluorenes (Boc-PFP-G(0-2)) were synthesized by Suzuki coupling 1,4-phenyldiboronic ester with dendritic monomers that were synthesized through generation-by-generation approach. The gel permeation chromatography (GPC) analyses showed that the weight-average molecular weight (M(w)) of Boc-PFP-G(0-2) was in the range of 11,400-20,400 Da with the polydispersity index (PDI) in the range of 1.32-1.96. Treatment of Boc-protected polymers with 6 M HCl in dioxane yielded cationic dendritic-conjugated polyfluorenes (PFP-GO(0-2)). They were soluble in common polar solvents such as DMSO, DMF, and water with absorption maxima between 345 and 379 nm. The solutions of PFP-GO(0-2) in water were highly fluorescent with emission maxima between 416 and 425 nm. Because higher generation dendrons could prevent the formation of pi-stacking aggregates of backbones of conjugated polymer, the fluorescence quantum efficiencies (QEs) of PFP-GO(0-2) enhance as the dendritic generation grew. The interactions between 25 mer double-stranded DNA (dsDNA) and PFP-G(0-2) were studied using ethidium bromide (EB) as fluorescent probe. The electrostatic bindings of PFP-G(0-2) with dsDNA/EB complex result in displacement of EB from DNA double helix to the solution accompanying by a quenching of EB fluorescence. The PFP-G(0-2) with highest generation of dendritic side chains possessed a highest charge density and could form most stable complex with dsDNA. (C) 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7462-7472, 2008
KeywordConjugated Polymers Dendritic-conjugated Polymers Dna Fluorescence Optical Properties Synthesis
DOI10.1002/pola.23051
Indexed BySCI
Language英语
WOS IDWOS:000260964400017
PublisherJOHN WILEY & SONS INC
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63992
Collection中国科学院化学研究所
Corresponding AuthorWang, Shu
AffiliationChinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yu, Minghui,Liu, Libing,Wang, Shu. Water-Soluble Dendritic-Conjugated Polyfluorenes: Synthesis, Characterization, and Interactions with DNA[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2008,46(22):7462-7472.
APA Yu, Minghui,Liu, Libing,&Wang, Shu.(2008).Water-Soluble Dendritic-Conjugated Polyfluorenes: Synthesis, Characterization, and Interactions with DNA.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,46(22),7462-7472.
MLA Yu, Minghui,et al."Water-Soluble Dendritic-Conjugated Polyfluorenes: Synthesis, Characterization, and Interactions with DNA".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 46.22(2008):7462-7472.
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