ICCAS OpenIR
Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride
Du, Hongyan1,2; Xiang, Junfeng1; Zhang, Yazhou1,2; Tang, Yalin1; Xu, Guangzhi1
2008
Source PublicationJOURNAL OF INORGANIC BIOCHEMISTRY
ISSN0162-0134
Volume102Issue:1Pages:146-149
AbstractThe action mechanism of vanadocene dichloride, Cp2VCl2 (CP = eta(5)-C5H5), has been investigated by interaction with human serum transferrin for its promising antitumor activities. Our results have shown that Cp2VCI2, binds to transferrin and form a new complex, and the calculated apparent association constant is 1.37 x 10(5) M-1 from the fluorescence quenching. Simultaneously, the variation of the secondary structure of transferrin occurs, most probably due to the coordination of the amino residues of protein with V-IV. It was evidenced that Cp is released free in solution after V-IV binding to transferrin by H-1 NMR measurements. These results have shown that Cp2VCl2, forms a complex with transferrin, which may provide a possible pathway in the transport and targeted delivery of the antitumor agent. (c) 2007 Elsevier Inc. All rights reserved.
KeywordTransferrin Vanadocene Dichloride Targeting Delivery Antitumor Activity
DOI10.1016/j.jinorgbio.2007.07.030
Indexed BySCI
Language英语
WOS IDWOS:000252523200015
PublisherELSEVIER SCIENCE INC
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63958
Collection中国科学院化学研究所
Corresponding AuthorTang, Yalin
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci,BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,et al. Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2008,102(1):146-149.
APA Du, Hongyan,Xiang, Junfeng,Zhang, Yazhou,Tang, Yalin,&Xu, Guangzhi.(2008).Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride.JOURNAL OF INORGANIC BIOCHEMISTRY,102(1),146-149.
MLA Du, Hongyan,et al."Binding of V-IV to human transferrin: Potential relevance to anticancer activity of vanadocene dichloride".JOURNAL OF INORGANIC BIOCHEMISTRY 102.1(2008):146-149.
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