ICCAS OpenIR
Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells
Wang Zhan-Feng2; Luo Yi-Nan2; Zheng Yong-Hui1; Han Hai-Ling; Hong Xin-Yu2; Jing Xia-Bin1
2008-08-01
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume29Issue:8Pages:1671-1676
AbstractNanoscale micelles of poly(ethylene)-b-poly(lactic acid)/paclitexal conjugate (PEG-PLA/PTX) were prepared and their interaction with rat brain glioma C, cells was examined by MTT, electron microscopy, flow cytometry(FCM), and confocal laser scanning microscopy(CLSM). The results show that the copolymer paclitaxel conjugate micelles can enter the cell, and are distributed in cytoplasm. The paclitaxel call be released the conjugate micelles can react with the genes in the cell nuclei, causing changes in the gene molecules, and thus, leading to changes in growth cycle of the cells, resulting in G(2)-M cell cycle arrest and inducing apoptosis of C-6 cells. Therefore, PEG-PLA/PTX micelles may be used in chemotherapy of brain glioma.
KeywordPaclitaxel Conjugate Poly (Ethylene)-b-Poly (Lactic Acid) Block coPolymer Flow Cytometry Tem Clsm Glioma C-6 Cells Apoptosis Cell Cycle
Indexed BySCI
Language英语
WOS IDWOS:000258807300038
PublisherHIGHER EDUCATION PRESS
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63876
Collection中国科学院化学研究所
Corresponding AuthorJing Xia-Bin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Jilin Univ, Clin Hosp 1, Dept Neurosurg, Changchun 130021, Peoples R China
Recommended Citation
GB/T 7714
Wang Zhan-Feng,Luo Yi-Nan,Zheng Yong-Hui,et al. Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(8):1671-1676.
APA Wang Zhan-Feng,Luo Yi-Nan,Zheng Yong-Hui,Han Hai-Ling,Hong Xin-Yu,&Jing Xia-Bin.(2008).Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(8),1671-1676.
MLA Wang Zhan-Feng,et al."Interaction of copolymer-paclitexal conjugate micelles with C-6 glioma cells".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.8(2008):1671-1676.
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