ICCAS OpenIR
Preparation and cell affinity of microtubular orientation-structured PLGA(70/30) blood vessel scaffold
Hu, Xixue; Shen, Hong; Yang, Fei; Bei, Jianzhong; Wang, Shenguo
2008-07-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume29Issue:21Pages:3128-3136
AbstractIn this study, a kind of microtubular orientation-structured blood vessel mimicking natural structure was fabricated with poly(lactide-co-glycolide)(70/30) (PLGA(70/30)) solutions in 1,4-dioxane by an improved thermal-induced phase separation (TIPS) technique. The effect of main factors of the TIPS technique, such as environmental temperature, temperature gradient and concentration of the polymer solution on the structure and morphology of formed vessel scaffold was investigated. It was observed that the outer-wall of the scaffold became thick obviously and the microtubules neighboring the outer-wall became disordered with environmental temperature increasing. The diameter of microtubules of vessel scaffolds reduced with temperature gradient increasing or concentration of the polymer solution increasing. By controlling parameters of the TIPS, the scaffolds with various morphologies could be manufactured, which had different diameters of microtubules. On the other hand, inner-diameter and outer-diameter of the vessel scaffolds could be controlled by adjusting size of the polyethylene mould. Cell affinity of the scaffolds was tested in vitro by using A10 cell as model cells. Results showed that the cells grew well in the vessel scaffolds which were modified by ammonia plasma treatment and then anchored with collagen. The cells could array along the direction of the microtubules. (c) 2008 Elsevier Ltd. All rights reserved.
KeywordBlood Vessel Scaffolds Plga(70/30) Microtubular Structure Thermal-induced Phase Separation (Tips) Technique Surface Modification Cell Affinity
DOI10.1016/j.biomaterials.2008.04.010
Indexed BySCI
Language英语
WOS IDWOS:000256655200009
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:77[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63828
Collection中国科学院化学研究所
Corresponding AuthorWang, Shenguo
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, BNLMS, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xixue,Shen, Hong,Yang, Fei,et al. Preparation and cell affinity of microtubular orientation-structured PLGA(70/30) blood vessel scaffold[J]. BIOMATERIALS,2008,29(21):3128-3136.
APA Hu, Xixue,Shen, Hong,Yang, Fei,Bei, Jianzhong,&Wang, Shenguo.(2008).Preparation and cell affinity of microtubular orientation-structured PLGA(70/30) blood vessel scaffold.BIOMATERIALS,29(21),3128-3136.
MLA Hu, Xixue,et al."Preparation and cell affinity of microtubular orientation-structured PLGA(70/30) blood vessel scaffold".BIOMATERIALS 29.21(2008):3128-3136.
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