ICCAS OpenIR
Single-molecule diffusion study of activated EGFR implicates its endocytic pathway
Xiao, Zeyu; Zhang, Wei; Yang, Yong; Xu, Li; Fang, Xiaohong
2008-05-02
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
Volume369Issue:2Pages:730-734
AbstractIn this work, we have imaged the lateral diffusion of activated epidermal growth factor receptor (EGFR) on cell membrane for studying its internalization pathway. After EGF activation, the mobility of individual EGFR molecules was measured and compared with that in the cells disrupted of clathrin-coated pits and caveolae, the two endocytosis-competent membrane microdomains. The results implicated that activated EGFR molecules associated with clathrin-coated pits but not caveolae at low doses of EGF, whereas they were located in these two domains at high EGF doses. It provided supporting evidence for the occurrence of both clathrin-dependent and caveolae-dependent EGFR endocytosis. (c) 2008 Elsevier Inc. All rights reserved.
KeywordSingle-molecule Study Fluorescence Egfr Diffusion Endocytosis
DOI10.1016/j.bbrc.2008.02.084
Indexed BySCI
Language英语
WOS IDWOS:000254676900074
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63808
Collection中国科学院化学研究所
Corresponding AuthorFang, Xiaohong
AffiliationChinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xiao, Zeyu,Zhang, Wei,Yang, Yong,et al. Single-molecule diffusion study of activated EGFR implicates its endocytic pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2008,369(2):730-734.
APA Xiao, Zeyu,Zhang, Wei,Yang, Yong,Xu, Li,&Fang, Xiaohong.(2008).Single-molecule diffusion study of activated EGFR implicates its endocytic pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,369(2),730-734.
MLA Xiao, Zeyu,et al."Single-molecule diffusion study of activated EGFR implicates its endocytic pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 369.2(2008):730-734.
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