ICCAS OpenIR
Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide)
Sun, Jing1,2; Chen, Xuesi1; Lu, Tiancheng1,2; Liu, Shi1,2; Tian, Huayu1,2; Guo, Zhaopei1,2; Jing, Xiabin1
2008-09-16
Source PublicationLANGMUIR
ISSN0743-7463
Volume24Issue:18Pages:10099-10106
AbstractA novel biodegradable diblock copolymer, poly(L-cysteine)-b-Poly(L-lactide) (PLC-b-PLLA), was synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of beta-benzyloxycarbonyl-L-Cysteine (ZLC-NCA) with amino-terminated Poly(L-lactide) (NH2-PLLA) as a macroinitiator in a convenient way. The diblock copolymer and its precursor were characterized by H-1 NMR, Fourier transform infrared (FT-IR), gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) measurements. The length of each block polymer could be tailored by molecular design and the ratios of feeding monomers. The cell adhesion and cell spread on the PZLC-b-PLLA and PLC-b-PLLA films were enhanced compared to those on pure PLA film. PLC-b-PLLA can self-assemble to form micelles in aqueous media. A pyrene probe is used to demonstrate the micelle formation of PLC-b-PLLA in aqueous solution. Due to the ease of disulfide exchange with thiols, the obtained micelles are reversible shell cross-linked (SCL) micelles. The morphology and size of the micelles are studied by dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM).
DOI10.1021/la8013877
Indexed BySCI
Language英语
WOS IDWOS:000259120500029
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:65[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63712
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Sun, Jing,Chen, Xuesi,Lu, Tiancheng,et al. Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide)[J]. LANGMUIR,2008,24(18):10099-10106.
APA Sun, Jing.,Chen, Xuesi.,Lu, Tiancheng.,Liu, Shi.,Tian, Huayu.,...&Jing, Xiabin.(2008).Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide).LANGMUIR,24(18),10099-10106.
MLA Sun, Jing,et al."Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide)".LANGMUIR 24.18(2008):10099-10106.
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