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Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG
Zhang HuiJuan1; Wang XueFei2,3; Wang Peng2; Pang SiPing1; Ai XiCheng2; Zhang JianPing2
2008-05-01
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN1006-9291
Volume51Issue:5Pages:452-456
AbstractThe binding properties between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin (TMPyP4) and the parallel DNA G-quadruplex (G4) of telomeric repeated sequence 5'-TTAGGG-3' have been characterized by means of circular dichroism, steady-state absorption, steady-state fluorescence and picosecond time-resolved fluorescence spectroscopies. The binding constant and the saturated binding number were determined as 1.29x10(6) (mol/L)(-1) and 3, respectively, according to steably-state absorption spectroscopy. Based on the findings by the use of time-resolved fluorescence spectroscopic technique, it is deduced that TMPyP4 binds to a DNA G-quadruplex with both the thread-intercalating and end-stacking modes and at the saturated binding state, one TMPyP4 molecule intercalates into the intervals of G-tetrads while the other two stack to the ends of the DNA G-quadruplex.
KeywordTmpyp4 Dna G-quadruplex Spectroscopic Technique Binding Mode
DOI10.1007/s11426-008-0051-2
Indexed BySCI
Language英语
WOS IDWOS:000255985300008
PublisherSCIENCE PRESS
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63686
Collection中国科学院化学研究所
Corresponding AuthorZhang HuiJuan
Affiliation1.Beijing Inst Technol, Sch Life Sci & Technol, Beijing 100081, Peoples R China
2.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhang HuiJuan,Wang XueFei,Wang Peng,et al. Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2008,51(5):452-456.
APA Zhang HuiJuan,Wang XueFei,Wang Peng,Pang SiPing,Ai XiCheng,&Zhang JianPing.(2008).Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG.SCIENCE IN CHINA SERIES B-CHEMISTRY,51(5),452-456.
MLA Zhang HuiJuan,et al."Interactions between meso-tetrakis(4-(N-methylpyridiumyl))porphyrin TMPyP4 and DNA G-quadruplex of telomeric repeated sequence TTAGGG".SCIENCE IN CHINA SERIES B-CHEMISTRY 51.5(2008):452-456.
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