Bio-distribution and metabolic paths of silica coated CdSeS quantum dots
Chen, Zhen1,5; Chen, Hu3; Meng, Huan1,5; Xing, Gengmei1; Gao, Xueyun1; Sun, Baoyun1; Shi, Xiaoli4,5; Yuan, Hui1; Zhang, Chengcheng1,5; Liu, Ru5; Zhao, Feng1; Zhao, Yuliang1,2,5; Fang, Xiaohong4
AbstractWith the rapid development of quantum dot (QD) technology, water-soluble QDs have the prospect of being used as a biological probe for specific diagnoses, but their biological behaviors in vivo are little known. Our recent in vivo studies concentrated on the bio-kinetics of QDs coated by hydroxyl group modified silica networks (the QDs are 21.3 +/- 2.0 nm in diameter and have maximal emission at 570 nm). Male ICR mice were intravenously given the water-soluble QDs with a single dose of 5 nmol/mouse. Inductively coupled plasma-mass spectrometry was used to measure the Cd-111 content to indicate the concentration of QDs in plasma, organs, and excretion samples collected at predetermined time intervals. Meanwhile, the distribution and aggregation state of QDs in tissues were also investigated by pathological examination and differential centrifugation. The plasma half-life and clearance of QDs were 19.8 +/- 3.2 h and 57.3 +/- 9.2 ml/h/kg, respectively. The liver and kidney were the main target organs for QDs. The QDs metabolized in three paths depending on their distinct aggregated states in vivo. A fraction of free QDs, maintaining their original form, could be filtered by glomerular capillaries and excreted via urine as small molecules within five days. Most QDs bound to protein and aggregated into larger particles that were metabolized in the liver and excreted via feces in vivo. After five days, 8.6% of the injected dose of aggregated QDs still remained in hepatic tissue and it was difficult for this fraction to clear. (C) 2008 Published by Elsevier Inc.
KeywordQuantum Dot Bio-kinetics Metabolic Path Nanoparticle Icp-ms
Indexed BySCI
WOS IDWOS:000258412200014
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Cited Times:121[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorXing, Gengmei
Affiliation1.Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
2.Natl Ctr Nanosci & Technol China, Beijing 100080, Peoples R China
3.Guizhou Normal Univ, Inst S China Karst, Guiyang 550001, Peoples R China
4.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100080, Peoples R China
5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Chen, Zhen,Chen, Hu,Meng, Huan,et al. Bio-distribution and metabolic paths of silica coated CdSeS quantum dots[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2008,230(3):364-371.
APA Chen, Zhen.,Chen, Hu.,Meng, Huan.,Xing, Gengmei.,Gao, Xueyun.,...&Fang, Xiaohong.(2008).Bio-distribution and metabolic paths of silica coated CdSeS quantum dots.TOXICOLOGY AND APPLIED PHARMACOLOGY,230(3),364-371.
MLA Chen, Zhen,et al."Bio-distribution and metabolic paths of silica coated CdSeS quantum dots".TOXICOLOGY AND APPLIED PHARMACOLOGY 230.3(2008):364-371.
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