ICCAS OpenIR
Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation
Xiao, Zeyu1; Ma, Xinyong1; Jiang, Yaxin1; Zhao, Zilong1; Lai, Bo2; Liao, Jieying2; Yue, Jiachang2; Fang, Xiaohong1
2008-04-03
Source PublicationJOURNAL OF PHYSICAL CHEMISTRY B
ISSN1520-6106
Volume112Issue:13Pages:4140-4145
AbstractThe transmembrane protein HER2, a member of the epidermal growth factor receptor family of tyrosine kinase, plays important roles in many fundamental cellular processes as well as the pathogenesis of many cancers. In this work, we have applied the single-molecule fluorescence microscopic method to study lateral mobility change of HER2 on activation by imaging and tracking individual GFP-tagged HER2 molecules on the membrane of living cells. The single HER2 molecules displayed different diffusion rates and modes. It was interesting to find that the mobility of HER2 increased upon stimulation by heregulin beta 1, the specific ligand of HER3. The faster diffusion was related to the tyrosine phosphorylation of HER2 or EGFR. The results provided new information for the understanding of HER2 activation and molecular mechanism of signal transduction through HER2/HER3 heterodimerization.
DOI10.1021/jp710302j
Indexed BySCI
Language英语
WOS IDWOS:000254540900033
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63634
Collection中国科学院化学研究所
Corresponding AuthorFang, Xiaohong
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Xiao, Zeyu,Ma, Xinyong,Jiang, Yaxin,et al. Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(13):4140-4145.
APA Xiao, Zeyu.,Ma, Xinyong.,Jiang, Yaxin.,Zhao, Zilong.,Lai, Bo.,...&Fang, Xiaohong.(2008).Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation.JOURNAL OF PHYSICAL CHEMISTRY B,112(13),4140-4145.
MLA Xiao, Zeyu,et al."Single-molecule study of lateral mobility of epidermal growth factor receptor 2/HER2 on activation".JOURNAL OF PHYSICAL CHEMISTRY B 112.13(2008):4140-4145.
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