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Surface property and in vitro biodegradation of microspheres fabricated by poly(epsilon-caprolactone-b-ethylene oxide) diblock copolymers
Yu, Guoqiang1,2; Zhang, Yu3; Shi, Xudong1,2; Li, Zhanshuang3; Gan, Zhihua1,2
2008-03-15
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
Volume84AIssue:4Pages:926-939
AbstractMicrospheres fabricated by biodegradable polymers with tunable surface properties show great potentials as microcarriers in in vitro cell cultivation and tissue engineering. Herein we reported a new method to regulate the surface property and morphology of microspheres via the synthesis of biodegradable amphiphilic block copolymers with adjustable compositions. The poly(E-caprolactone-b-ethylene oxide) diblock copolymers with functional amino end groups bonding to the PEO block (PCL-b-PEO-NH2) were synthesized by sequential ring-opening polymerization with potassium bis(trimethylsilyl) amide as initiator. The copolymers were characterized by gel permeation chromatography (GPC) and H-1 NMR, and then used to fabricate microspheres by w/o/w double emulsion solvent evaporation technique. The surface properties of microspheres were studied by means of scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). The results indicated that both the fabrication conditions and copolymer composition have great influences on the surface morphology and property of microspheres. The reactive amino functional groups are dominantly located on the surface of microspheres. The in vitro degradation of microspheres was studied by following the morphological changes of microspheres. The influences of hydrophilic PEO out-layers on the enzymatic degradation of microspheres were discussed. These microspheres with controllable surface morphology and amino functional groups are expected to be promising alternatives for the further biomimetic modification to promote cell growth on materials. (C) 2007 Wiley Periodicals, Inc.
KeywordMicrospheres Biodegradable Amphiphilic Block Copolymers Enzymatic Degradation Surface Property
DOI10.1002/jbm.a.31325
Indexed BySCI
Language英语
WOS IDWOS:000253287700009
PublisherWILEY-LISS
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63586
Collection中国科学院化学研究所
Corresponding AuthorGan, Zhihua
Affiliation1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Joint Lab Polymer Sci Mat, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Sch, Div Chem & Chem Engn, Beijing 100039, Peoples R China
3.Harbin Engn Univ, Coll Mat Sci & Chem Engn, Dept Chem Mat, Harbin 150001, Peoples R China
Recommended Citation
GB/T 7714
Yu, Guoqiang,Zhang, Yu,Shi, Xudong,et al. Surface property and in vitro biodegradation of microspheres fabricated by poly(epsilon-caprolactone-b-ethylene oxide) diblock copolymers[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2008,84A(4):926-939.
APA Yu, Guoqiang,Zhang, Yu,Shi, Xudong,Li, Zhanshuang,&Gan, Zhihua.(2008).Surface property and in vitro biodegradation of microspheres fabricated by poly(epsilon-caprolactone-b-ethylene oxide) diblock copolymers.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,84A(4),926-939.
MLA Yu, Guoqiang,et al."Surface property and in vitro biodegradation of microspheres fabricated by poly(epsilon-caprolactone-b-ethylene oxide) diblock copolymers".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 84A.4(2008):926-939.
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