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The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine)
Thompson, Colin J.1; Ding, Caixia2; Qu, Xiaozhong2; Yang, Zhenzhong2; Uchegbu, Ijeoma F.3; Tetley, Laurence4; Cheng, Woei Ping1
2008-11-01
Source PublicationCOLLOID AND POLYMER SCIENCE
ISSN0303-402X
Volume286Issue:13Pages:1511-1526
AbstractTwelve novel poly(allylamine) (PAA)-based, comb-shaped amphiphilic polymers have been developed. Hydrophobic groups of cetyl, palmitoyl and cholesteryl were randomly grafted to PAA and quaternisation was carried out on some modified polymers. Polymers were characterised using (1)H NMR, elemental analysis and differential scanning calorimetry. All polymers formed nano self-assemblies in the aqueous solution with a positive zeta potential and were able to encapsulate a hydrophobic agent, methyl orange, in the core. The critical aggregation concentration (CAC) and the microviscosity were found to be dependent on the polymer hydrophobicity. Being the most hydrophobic polymer, cholesteryl-grafted PAA had the lowest CAC (0.02 mg mL(-1)) and the highest microviscosity. They appeared to form dense nanoparticles and were transformed into novel nanostructures in the presence of free cholesterol. Palmitoyl-grafted polymers formed nanoparticles while cetyl-grafted polymers formed polymeric micelles. The flexibility of cetyl chains possibly resulted in the formation of multicore polymeric micelles.
KeywordSelf-assembly Nanoparticles Micelle Amphiphilic Polymer
DOI10.1007/s00396-008-1925-8
Indexed BySCI
Language英语
WOS IDWOS:000259720600007
PublisherSPRINGER
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63582
Collection中国科学院化学研究所
Corresponding AuthorCheng, Woei Ping
Affiliation1.Robert Gordon Univ, Sch Pharm & Life Sci, Aberdeen AB10 1FR, Scotland
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
3.Univ London, Sch Pharm, London WC1N 1AX, England
4.Univ Glasgow, Integrated Microscopy Facil, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Recommended Citation
GB/T 7714
Thompson, Colin J.,Ding, Caixia,Qu, Xiaozhong,et al. The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine)[J]. COLLOID AND POLYMER SCIENCE,2008,286(13):1511-1526.
APA Thompson, Colin J..,Ding, Caixia.,Qu, Xiaozhong.,Yang, Zhenzhong.,Uchegbu, Ijeoma F..,...&Cheng, Woei Ping.(2008).The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine).COLLOID AND POLYMER SCIENCE,286(13),1511-1526.
MLA Thompson, Colin J.,et al."The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine)".COLLOID AND POLYMER SCIENCE 286.13(2008):1511-1526.
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