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Orthogonal test of preparation of poly(L-glutamic acid) through deprotection of poly(gamma-benzyl L-glutamate)
Xie Yong-Tao1; Yin Jing-Bo1; Zhao Chang-Wen2; Chen Xue-Si2
2008-01-10
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume29Issue:1Pages:197-200
AbstractPoly(L-glutamic acid) (PLGA) was prepared by removing the benzyl groups from poly(gamma-benzyl L-glutamate) (PBLG) through 33 % (volume fraction) HBr and acetic acid solution. Orthogonal test method was applied to study the effect of temperature, the reacting time, the quantity of the solvent and 33 % HBr and acetic acid solution on the molecular weight of PLGA during the process of deprotection. The result show that PLGA molecular weight would be decreased with the increase of the temperature, the reacting time, and the solvent quantity, for the degradation of PBLG. However, the effect of HBr was reverse, for the acidity of 33% HBr and acetic acid solution was weaker than that of dichloroacedic acid (Cl2HAc) and PBLG could not be dissolved in 33% HBr and acetic acid solution.
KeywordPoly(Gamma-benzyl L-glulamate) Poly(L-glutamic Acid) Deproteetion Orthogonal Test
Indexed BySCI
Language英语
WOS IDWOS:000252618000041
PublisherHIGHER EDUCATION PRESS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63508
Collection中国科学院化学研究所
Corresponding AuthorYin Jing-Bo
Affiliation1.Shanghai Univ, Dept Polymer Mat, Shanghai 201800, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Xie Yong-Tao,Yin Jing-Bo,Zhao Chang-Wen,et al. Orthogonal test of preparation of poly(L-glutamic acid) through deprotection of poly(gamma-benzyl L-glutamate)[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2008,29(1):197-200.
APA Xie Yong-Tao,Yin Jing-Bo,Zhao Chang-Wen,&Chen Xue-Si.(2008).Orthogonal test of preparation of poly(L-glutamic acid) through deprotection of poly(gamma-benzyl L-glutamate).CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,29(1),197-200.
MLA Xie Yong-Tao,et al."Orthogonal test of preparation of poly(L-glutamic acid) through deprotection of poly(gamma-benzyl L-glutamate)".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 29.1(2008):197-200.
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