ICCAS OpenIR
Finding multiple target optimal intervention in disease-related molecular network
Yang, Kun1,2; Bai, Hongjun1,2; Qi Ouyang2; Lai, Luhua1,2; Tang, Chao2,3
2008-11-01
Source PublicationMOLECULAR SYSTEMS BIOLOGY
ISSN1744-4292
Volume4
AbstractDrugs against multiple targets may overcome the many limitations of single targets and achieve a more effective and safer control of the disease. Numerous high-throughput experiments have been performed in this emerging field. However, systematic identification of multiple drug targets and their best intervention requires knowledge of the underlying disease network and calls for innovative computational methods that exploit the network structure and dynamics. Here, we develop a robust computational algorithm for finding multiple target optimal intervention (MTOI) solutions in a disease network. MTOI identifies potential drug targets and suggests optimal combinations of the target intervention that best restore the network to a normal state, which can be customer designed. We applied MTOI to an inflammation-related network. The well-known side effects of the traditional non-steriodal anti-inflammatory drugs and the recently recalled Vioxx were correctly accounted for in our network model. A number of promising MTOI solutions were found to be both effective and safer.
KeywordAnti-inflammatory Arachidonic Acid Metabolic Network Drug Efficacy Prediction Multiple Target Drug Design Network-based Drug Design
DOI10.1038/msb.2008.60
Indexed BySCI
Language英语
WOS IDWOS:000261394500001
PublisherNATURE PUBLISHING GROUP
Citation statistics
Cited Times:123[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63466
Collection中国科学院化学研究所
Corresponding AuthorLai, Luhua
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
3.Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA
Recommended Citation
GB/T 7714
Yang, Kun,Bai, Hongjun,Qi Ouyang,et al. Finding multiple target optimal intervention in disease-related molecular network[J]. MOLECULAR SYSTEMS BIOLOGY,2008,4.
APA Yang, Kun,Bai, Hongjun,Qi Ouyang,Lai, Luhua,&Tang, Chao.(2008).Finding multiple target optimal intervention in disease-related molecular network.MOLECULAR SYSTEMS BIOLOGY,4.
MLA Yang, Kun,et al."Finding multiple target optimal intervention in disease-related molecular network".MOLECULAR SYSTEMS BIOLOGY 4(2008).
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