ICCAS OpenIR
Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform
Wu, Yan-Chao1,2; Li, Hui-Jing1; Liu, Li1; Wang, Dong1; Yang, Hua-Zheng2; Chen, Yong-Jun1
2008-03-01
Source PublicationJOURNAL OF FLUORESCENCE
ISSN1053-0509
Volume18Issue:2Pages:357-363
AbstractAn efficient, fast and facile pyrazolo[1,5-a]pyrimidine synthetic protocol has been established by the condensation of aminopyrazoles with 1,3-dicarbonyl components in AcOH/H2SO4 system. The pyrazolo[1,5-a]pyrimidine sulfides were selectively oxidized to the sulfones via a temperature-controlled stepwise oxidative fashion. The correlation between the substitution patterns of these pyrazolo[1,5-a]pyrimidines and their fluorescent spectroscopic properties were further examined, which provided the fundamentals for their potential applications in the development of new fluorescent probes. Red-shifts were easily achieved by the incorporation of unsaturated groups at the 5- and 7-positions, which suggested an approach for synthesizing long wavelength pyrazolo[1,5-a]pyrimidine dyes. The fluorescent spectroscopic properties were found to be sensitive to the hydroxy-containing and carbonyl-containing media such as alcohol and acetone, which helps to confirm the promising perspectives of further investigations in this area.
KeywordFluorophore Heterocycle Fluorescence Pyrazolo[1 5-a]Pyrimidine
DOI10.1007/s10895-007-0275-0
Indexed BySCI
Language英语
WOS IDWOS:000253896400014
PublisherSPRINGER/PLENUM PUBLISHERS
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63434
Collection中国科学院化学研究所
Corresponding AuthorWu, Yan-Chao
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China
2.Nankai Univ, Inst Element Organ Chem, Tianjin 300071, Peoples R China
Recommended Citation
GB/T 7714
Wu, Yan-Chao,Li, Hui-Jing,Liu, Li,et al. Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform[J]. JOURNAL OF FLUORESCENCE,2008,18(2):357-363.
APA Wu, Yan-Chao,Li, Hui-Jing,Liu, Li,Wang, Dong,Yang, Hua-Zheng,&Chen, Yong-Jun.(2008).Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform.JOURNAL OF FLUORESCENCE,18(2),357-363.
MLA Wu, Yan-Chao,et al."Efficient construction of pyrazolo[1,5-a]pyrimidine scaffold and its exploration as a new heterocyclic fluorescent platform".JOURNAL OF FLUORESCENCE 18.2(2008):357-363.
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