ICCAS OpenIR
A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation
Xie, Zhigang1,2; Hu, Xiuli1,2; Chen, Xuesi1; Lu, Tiancheng1,2; Liu, Shi1; Jing, Xiabin1
2008-12-05
Source PublicationJOURNAL OF APPLIED POLYMER SCIENCE
ISSN0021-8995
Volume110Issue:5Pages:2961-2970
AbstractA diblcok copolymer monomethoxy poly (ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate) (MPEG-b-P(LA-co-MCC)) was obtained by copolymerization of L-lactide (LA) and 2-methyl-2-benzoxycarbonyl-propylene carbonate (MBC) and subsequent catalytic hydrogenation. The pendant carboxyl groups of the copolymer MPEG-b-P(LA-co-MCC) were conjugated with antitumor drug docetaxel and tripeptide arginine-glycine-aspartic acid (RGD), respectively. H-1-NMR spectra confirmed the structure of the copolymer MPEG-b-P(LA-co-MCC/docetaxel) and MPEG-b-P(LA-co-MCC/RGD). In vitro antitumor assay indicates that the MPEG-b-P(LA-co-MCC/docetaxel) conjugate shows high cytotoxic activity against HeLa cancer cells. Cell adhesion and spreading experiment shows that copolymer MPEG-b-P(LA-co-MCC/RGD) is of benefit to cell adherence and is a promising biodegradable material for cell and tissue engineering. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 110: 2961-2970,2008
KeywordBiodegradable Block Copolymers Docetaxel Rgd
DOI10.1002/app.28900
Indexed BySCI
Language英语
WOS IDWOS:000260102800057
PublisherJOHN WILEY & SONS INC
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63172
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Xie, Zhigang,Hu, Xiuli,Chen, Xuesi,et al. A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2008,110(5):2961-2970.
APA Xie, Zhigang,Hu, Xiuli,Chen, Xuesi,Lu, Tiancheng,Liu, Shi,&Jing, Xiabin.(2008).A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation.JOURNAL OF APPLIED POLYMER SCIENCE,110(5),2961-2970.
MLA Xie, Zhigang,et al."A Biodegradable Diblcok Copolymer Poly(ethylene glycol)-block-poly(L-lactide-co-2-methyl-2-carboxyl-propylene carbonate): Docetaxel and RGD Conjugation".JOURNAL OF APPLIED POLYMER SCIENCE 110.5(2008):2961-2970.
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