ICCAS OpenIR
Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization
Hu, Xiuli1,2; Liu, Shi1; Chen, Xuesi1; Mo, Guojun1,2; Xie, Zhigang1,2; Jing, Xiabin1
2008-02-01
Source PublicationBIOMACROMOLECULES
ISSN1525-7797
Volume9Issue:2Pages:553-560
AbstractA new biodegradable amphiphilic block copolymer, poly(ethylene glycol)-b-poly(L-factide-co-9-phenyl-2,4,8, 10-tetraoxaspiro[5,5]undecan-3-one) [PEG-b-P(LA-co-PTO)], was successfully prepared by ring-opening polymerization (ROP) Of L-lactide (LA) and functionalized carbonate monomer 9-phenyl-2,4,8,10-tetraozaspiro[5,5]undecan-3-one (PTO) in the presence of monohydroxyl poly(ethylene glycol) as macroinitiator using Sn(Oct)(2) as catalyst. NMR, FT-IR, and GPC studies confirmed the copolymer structure. It could self-assemble into micelles in aqueous solution with critical micelle concentration (CMC) in the magnitude of mg/L, which changed with the composition of the copolymer. After catalytic hydrogenation, copolymers with active hydroxyl groups were obtained. Adhesion and proliferation of Vero cells on the copolymer films showed that the synthesized copolymers were good biocompatible materials. In vitro degradation of the copolymer before and after deprotection was investigated in the presence of proteinase K. The free hydroxyl groups on the copolymers were capable of further modification with biotin. This new amphiphilic block copolymer has great potential for both drug encapsulation and conjugate because of its low CMC and the presence of active hydroxyl groups.
DOI10.1021/bm701092j
Indexed BySCI
Language英语
WOS IDWOS:000253102100020
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:65[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63136
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xiuli,Liu, Shi,Chen, Xuesi,et al. Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization[J]. BIOMACROMOLECULES,2008,9(2):553-560.
APA Hu, Xiuli,Liu, Shi,Chen, Xuesi,Mo, Guojun,Xie, Zhigang,&Jing, Xiabin.(2008).Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization.BIOMACROMOLECULES,9(2),553-560.
MLA Hu, Xiuli,et al."Biodegradable amphiphilic block copolymers bearing protected hydroxyl groups: Synthesis and characterization".BIOMACROMOLECULES 9.2(2008):553-560.
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