ICCAS OpenIR
A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives
Wang, Nengdong; Xiang, Jing; Ma, Zhibo; Quan, Junmin; Chen, Jiahua; Yang, Zhen1
2008-11-01
Source PublicationJOURNAL OF COMBINATORIAL CHEMISTRY
ISSN1520-4766
Volume10Issue:6Pages:825-834
AbstractAn efficient and rapid solution-phase combinatorial synthesis of the SAG library was developed. The salient features for this library synthesis is the application of carbothioamide-derived palladacycle-catalyzed Suzuki coupling reactions for the parallel synthesis of a series of pyridine-based biaryl aldehydes under aerobic conditions and a direct N-alkylation of carbarnates using NaH as base in DMF in the presence of catalytic amount of water. The resultant library has been submitted to biological screening to evaluate their potential role in the regulation of Hedgehog pathway.
DOI10.1021/cc800025n
Indexed BySCI ; IC ; CCR
Language英语
WOS IDWOS:000260851400006
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/63098
Collection中国科学院化学研究所
Corresponding AuthorYang, Zhen
Affiliation1.Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, BNLMS, Coll Chem, State Key Lab Nat & Biomimet Drugs,Sch Pharmaceut, Beijing 100871, Peoples R China
3.Peking Univ, Lab Chem Genom, Shenzhen Grad Sch, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Nengdong,Xiang, Jing,Ma, Zhibo,et al. A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives[J]. JOURNAL OF COMBINATORIAL CHEMISTRY,2008,10(6):825-834.
APA Wang, Nengdong,Xiang, Jing,Ma, Zhibo,Quan, Junmin,Chen, Jiahua,&Yang, Zhen.(2008).A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives.JOURNAL OF COMBINATORIAL CHEMISTRY,10(6),825-834.
MLA Wang, Nengdong,et al."A Concise and Diversity-Oriented Approach to the Synthesis of SAG Derivatives".JOURNAL OF COMBINATORIAL CHEMISTRY 10.6(2008):825-834.
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