ICCAS OpenIR
Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging
Ma, Xinyong; Wang, Qiang; Jiang, Yaxin; Xiao, Zeyu; Fang, Xiaohong; Chen, Ye-Guang
2007-04-27
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN0006-291X
Volume356Issue:1Pages:67-71
AbstractIn this report, we investigated the lateral diffusion of transforming growth factor beta (TGF-beta) type I receptor (T beta RI) in living cells by imaging and tracking individual green fluorescent protein tagged T beta RI on the cell membrane. We found that when co-expressed with TGF-beta type 11 receptor (T beta RII), the mobility of T beta RI decreased significantly after TGF-beta 1 stimulation. However, in the cells that had been depleted of cholesterol with Nystatin or methyl-beta-cyclodextrin, the diffusion rate of T beta RI was not changed by TGF-beta 1 treatment. Our observations suggest that membrane lipid-rafts provide an environment that facilitates the association of T beta RI and T beta RII for cell signaling. (c) 2007 Elsevier Inc. All rights reserved.
KeywordSingle-molecule Fluorescence Imaging Mobility Tgf-beta 1 Tgf-beta Receptor Lipid-raft
DOI10.1016/j.bbrc.2007.02.080
Indexed BySCI
Language英语
WOS IDWOS:000245419300011
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/62930
Collection中国科学院化学研究所
Corresponding AuthorFang, Xiaohong
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Tsing Hua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Ma, Xinyong,Wang, Qiang,Jiang, Yaxin,et al. Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,356(1):67-71.
APA Ma, Xinyong,Wang, Qiang,Jiang, Yaxin,Xiao, Zeyu,Fang, Xiaohong,&Chen, Ye-Guang.(2007).Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,356(1),67-71.
MLA Ma, Xinyong,et al."Lateral diffusion of TGF-beta type I receptor studied by single-molecule imaging".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 356.1(2007):67-71.
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