ICCAS OpenIR
Micellization of dissymmetric cationic gemini surfactants and their interaction with Dimyristoylphosphatidylcholine vesicles
Fan, Yanru; Li, Yajuan; Cao, Meiwen; Wang, Jinben; Wang, Yilin; Thomas, Robert K.
2007-11-06
Source PublicationLANGMUIR
ISSN0743-7463
Volume23Issue:23Pages:11458-11464
AbstractThe micellization process of a series of dissymmetric cationic gemini surfactants [CmH2m+1(CH3)(2)N(CH2)(6)N(CH3)(2)C6H13 ]Br-2 (designated as m-6-6 with m = 12,14, and 16) and their interaction with dimyristoylphosphatidylcholine (DMPC) vesicles have been investigated. In the micellization process of these gemini surfactants themselves, critical micelle concentration (cmc), micelle ionization degree, and enthalpies of micellization (Delta H-mic) were determined, from which Gibbs free energies of micellization (Delta G(mic) and entropy of micellization (Delta S-mic) were derived. These properties were found to be influenced significantly by the dissymmetry in the surfactant structures. The phase diagrams for the solubilization of DMPC vesicles by the gemini surfactants were constructed from calorimetric results combining with the results of turbidity and dynamic light scattering. The effective surfactant to lipid ratios in the mixed aggregates at saturation (R-e(sol)) and solubilization (R-e(sat)) were derived. For the solubilization of DMPC vesicles, symmetric 12-6-12 is more effective than corresponding single-chain surfactant DTAB, whereas the dissymmetric m-6-6 series are more effective than symmetric 12-6-12, and 16-6-6 is the most effective. The chain length mismatch between DMPC and the gemini surfactants may be responsible for the different R-e values. The transfer enthalpy per mole of surfactant within the coexistence range may be associated with the total hydrophobicity of the alkyl chains of gemini surfactants. The transfer enthalpies of surfactant from micelles to bilayers are always endothermic due to the dehydration of headgroups and the disordering of lipid acyl chain packing during the vesicle solubilization.
DOI10.1021/la701493s
Indexed BySCI
Language英语
WOS IDWOS:000250584500025
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/62874
Collection中国科学院化学研究所
Corresponding AuthorWang, Yilin
Affiliation1.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, Beijing 100080, Peoples R China
2.Univ Oxford, Phys & Theoret Chem Lab, Oxford OX1 3QZ, England
Recommended Citation
GB/T 7714
Fan, Yanru,Li, Yajuan,Cao, Meiwen,et al. Micellization of dissymmetric cationic gemini surfactants and their interaction with Dimyristoylphosphatidylcholine vesicles[J]. LANGMUIR,2007,23(23):11458-11464.
APA Fan, Yanru,Li, Yajuan,Cao, Meiwen,Wang, Jinben,Wang, Yilin,&Thomas, Robert K..(2007).Micellization of dissymmetric cationic gemini surfactants and their interaction with Dimyristoylphosphatidylcholine vesicles.LANGMUIR,23(23),11458-11464.
MLA Fan, Yanru,et al."Micellization of dissymmetric cationic gemini surfactants and their interaction with Dimyristoylphosphatidylcholine vesicles".LANGMUIR 23.23(2007):11458-11464.
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