ICCAS OpenIR
Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase
Liu Ying; Zheng Teng-Fei; Jin Feng; Zhou Lu; Liu Zhen-Ming; Wei Ping; Lai Lu-Hua
2007-08-28
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume65Issue:16Pages:1707-1712
AbstractSevere acute respiratory syndrome(SARS) coronavirus 3C-like proteinase is the key enzyme for the maturation of the virus and has been proposed to be a key target for structure based drug design against SARS. In this paper, based on the three-dimensional structure of SARS coronavirus 3C-like proteinase, the available chemical database (ACD) and clinical drug databases were used for virtual screening, and the candidate non-peptidic compounds were purchased or synthesized. Several human rhinovirus (HRV) 3C protease inhibitors were also synthesized. All the compounds were tested against SARS 3C-like proteinase bioassay. Two types of compounds including hydroxyzine dihydrochloride, a well known antihistamine, were found to inhibit the enzyme and SARS virus in cell cultivating; one of the isatin compounds shows significant inhibition with an IC50 of (0.76 +/- 0.02) mu mol center dot L-1 . The primary result. suggested that drugs in clinical usage can be developed for new purpose.
KeywordSars Coronavirus 3c-like Proteinase Virtual Screen Non-peptidic Inhibitor Bioassay
Indexed BySCI
Language英语
WOS IDWOS:000249347100031
PublisherSCIENCE CHINA PRESS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/62784
Collection中国科学院化学研究所
Corresponding AuthorLiu Ying
Affiliation1.Peking Univ, Coll Chem & Mol Engn, State Key Lab Struct Chem Unstable & Stable Speci, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Liu Ying,Zheng Teng-Fei,Jin Feng,et al. Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase[J]. ACTA CHIMICA SINICA,2007,65(16):1707-1712.
APA Liu Ying.,Zheng Teng-Fei.,Jin Feng.,Zhou Lu.,Liu Zhen-Ming.,...&Lai Lu-Hua.(2007).Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase.ACTA CHIMICA SINICA,65(16),1707-1712.
MLA Liu Ying,et al."Design and bioassay of non-peptidic inhibitors of SARS coronavirus 3C-like proteinase".ACTA CHIMICA SINICA 65.16(2007):1707-1712.
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