ICCAS OpenIR
Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery
Chen, Li; Xie, Zhigang; Hu, Junli; Chen, Xuesi; Jing, Xiabin
2007-10-01
Source PublicationJOURNAL OF NANOPARTICLE RESEARCH
ISSN1388-0764
Volume9Issue:5Pages:777-785
AbstractA novelty approach to self-assembling stereocomplex micelles by enantiomeric PLA-PEG block copolymers as a drug delivery carrier was described. The particles were encapsulated by enantiomeric PLA-PEG stereocomplex to form nanoscale micelles different from the microspheres or the single micelles by PLLA or PDLA in the reported literatures. First, the block copolymers of enantiomeric poly(L-lactide)-poly(ethylene-glycol) (PLLA-PEG) and poly(D-lactide)-poly(ethylene-glycol) (PDLA-PEG) were synthesized by the ring-opening polymerization of L-lactide and D-lactide in the presence of monomethoxy PEG, respectively. Second, the stereocomplex block copolymer micelles were obtained by the self-assembly of the equimolar mixtures of enantiomeric PLA-PEG copolymers in water. These micelles possessed partially the crystallized hydrophobic cores with the critical micelle concentrations (cmc) in the range of 0.8-4.8 mg/l and the mean hydrodynamic diameters ranging from 40 to 120 nm. The micelle sizes and cmc values obviously depended on the hydrophobic block PLA content in the copolymer. Compared with the single PLLA-PEG or PDLA PEG micelles, the cmc values of the stereocomplex micelles became lower and the sizes of the stereocomplex micelles formed smaller. And lastly, the stereocomplex micelles encapsulated with rifampin were tested for the controlled release application. The rifampin loading capacity and encapsulation efficiency by the stereocomplex micelles were higher than those by the single polymer micelles, respectively. The drug release time in vitro was depending on the composites of the block copolymers and also could be controlled by the polymer molecular weight and the morphology of the polymer micelles.
KeywordPlla-peg Pdla-peg Stereocomplex Micelle Rifampin Drug Delivery Controlled Release Nanobiomedicine Nanotechnology
DOI10.1007/s11051-006-9103-8
Indexed BySCI
Language英语
WOS IDWOS:000247471500007
PublisherSPRINGER
Citation statistics
Cited Times:81[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/62684
Collection中国科学院化学研究所
Corresponding AuthorChen, Xuesi
Affiliation1.Acad Sinica, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.NE Normal Univ, Dept Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Chen, Li,Xie, Zhigang,Hu, Junli,et al. Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery[J]. JOURNAL OF NANOPARTICLE RESEARCH,2007,9(5):777-785.
APA Chen, Li,Xie, Zhigang,Hu, Junli,Chen, Xuesi,&Jing, Xiabin.(2007).Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery.JOURNAL OF NANOPARTICLE RESEARCH,9(5),777-785.
MLA Chen, Li,et al."Enantiomeric PLA-PEG block copolymers and their stereocomplex micelles used as rifampin delivery".JOURNAL OF NANOPARTICLE RESEARCH 9.5(2007):777-785.
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