ICCAS OpenIR
Highly sensitive gold nanoparticles biosensor chips modified with a self-assembled bilayer for detection of Con A
Guo, Caixin; Boullanger, Paul; Jiang, Long; Liu, Tao
2007-03-15
Source PublicationBIOSENSORS & BIOELECTRONICS
ISSN0956-5663
Volume22Issue:8Pages:1830-1834
AbstractIn this paper, an improved method for detection of Concanavalin A (Con A) with label-free optical biosensors is reported. 1-Dodecanethiol (DDT) was self-assembled onto gold nanoparticles which were deposited on glass slides, and then glycolipid molecules were inserted into dodecanethiol by physical interactions only. The recognition between Con A and carbohydrate was observed by UV-vis spectrophotometry. The absorption spectrum shifted when Con A was bound to the sugar residues of glycolipids immobilized onto nanogold slides, while almost no spectrum change was observed when another nonspecific protein molecule met the nanogold slides. The self-assembled bilayer on nanogold substrates had very high sensitivity for Con A, the minimum detection concentration of Con A can be down to 0.1 nM. In addition to the ultra sensitivity for investigating carbohydrate-lectin interaction, the self-assembled bilayer structure, is expected to replace many receptors which require time-consuming organic syntheses for the fixation to the transducer. The simplicity and sensitivity of this biosensor architecture once again show the prospect of nanogold application in biosensor. (c) 2006 Elsevier B.V. All rights reserved.
KeywordGold Nanoparticles Biosensor Chips Self-assembled Bilayer Con a
DOI10.1016/j.bios.2006.09.006
Indexed BySCI
Language英语
WOS IDWOS:000244676300038
PublisherELSEVIER ADVANCED TECHNOLOGY
Citation statistics
Cited Times:59[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/62620
Collection中国科学院化学研究所
Corresponding AuthorLiu, Tao
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Colloid & Interface Sci, Beijing 100080, Peoples R China
2.Univ Lyon 1, UMR 5181, Lab Chim Organ Glycochim 2, F-69622 Villeurbanne, France
Recommended Citation
GB/T 7714
Guo, Caixin,Boullanger, Paul,Jiang, Long,et al. Highly sensitive gold nanoparticles biosensor chips modified with a self-assembled bilayer for detection of Con A[J]. BIOSENSORS & BIOELECTRONICS,2007,22(8):1830-1834.
APA Guo, Caixin,Boullanger, Paul,Jiang, Long,&Liu, Tao.(2007).Highly sensitive gold nanoparticles biosensor chips modified with a self-assembled bilayer for detection of Con A.BIOSENSORS & BIOELECTRONICS,22(8),1830-1834.
MLA Guo, Caixin,et al."Highly sensitive gold nanoparticles biosensor chips modified with a self-assembled bilayer for detection of Con A".BIOSENSORS & BIOELECTRONICS 22.8(2007):1830-1834.
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