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A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity
Tan, Li; Zhang, Xiu-Feng; Yan, Bao-Zhen; Shi, Hai-Ming; Du, Li-Bo; Zhang, Ya-Zhou; Wang, Lan-Fen; Tang, Ya-Lin; Liu, Yang
2007-11-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume17Issue:22Pages:6311-6315
AbstractBioactivity guided fractionation of the ethanolic extract of the whole plants of Lespedeza virgata (Thunb.) DC. resulted in the isolation of a novel flavonoid (1) along with five known compounds 2-6. The molecular and structural formula as well as the stereochemistry of compound 1 were determined using data obtained from (1)H and (13)C NMR spectra, DEPT135 and by 2D HSQC, HMBC, (1)H-(1)H correlated spectroscopy ((1)H-(1)H COSY), and nuclear overhauser effect spectroscopy (NOESY) experiments. The superoxide anion scavenging activities of all isolated compounds were evaluated by the hypoxanthine nitro blue tetrazolium and ESR methods and the new compound 1 showed the strongest antioxidative activity 95.79% (IC(50) = 0.14 mg/ml). (C) 2007 Elsevier Ltd. All rights reserved.
KeywordLespedeza Virgata Flavonoid Nmr Antioxidative Activity
DOI10.1016/j.bmcl.2007.09.003
Indexed BySCI
Language英语
WOS IDWOS:000250906200054
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/62520
Collection中国科学院化学研究所
Corresponding AuthorLiu, Yang
Affiliation1.Chinese Acad Sci, Inst Chem, State Key Lab SCUSS, Beijing 100080, Peoples R China
2.Beijing Univ Chem Technol, Fac Sci, Beijing 100029, Peoples R China
3.Peking Univ, Ctr Hlth Sci, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Tan, Li,Zhang, Xiu-Feng,Yan, Bao-Zhen,et al. A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2007,17(22):6311-6315.
APA Tan, Li.,Zhang, Xiu-Feng.,Yan, Bao-Zhen.,Shi, Hai-Ming.,Du, Li-Bo.,...&Liu, Yang.(2007).A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,17(22),6311-6315.
MLA Tan, Li,et al."A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17.22(2007):6311-6315.
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