ICCAS OpenIR
Exploring the optimal ratio of D-glucose/L-aspartic acid for targeting carbon dots toward brain tumor cells
Qiao, Lihong1; Sun, Tingting2,3; Zheng, Xiaohua2,3; Zheng, Min1; Xie, Zhigang2
2018-04-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume85Pages:1-6
AbstractTargeting imaging to the desired site of action can increase the accuracy and effectiveness of diagnostic and treatment. In this work, a series of fluorescent carbon dots (CDs) were prepared by varying molar ratios of D-glucose (Glu) to L-aspartic acid (Asp). Their photophysical properties, morphologies and structures were investigated in detail. More important, the targeting ability was screened by confocal laser scanning microscopy and flow cytometry. The results indicate that CDs prepared from the optimal molar ratio of Glu/Asp (7:3) exhibit the highest targeting ability on C6 glioma cells, This work highlights the interplay of molecular design and corresponding functions, and open new possibility of developing state-of-art nanoparticles for biomedical applications.
KeywordOptimal Ratio D-glucose L-aspartic Acid Carbon Dots Targeting Brain Cancer
DOI10.1016/j.msec.2017.12.011
Indexed BySCI
Language英语
WOS IDWOS:000428496400001
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/46132
Collection中国科学院化学研究所
Corresponding AuthorZheng, Min; Xie, Zhigang
Affiliation1.Changchun Univ Technol, Sch Chem & Life Sci, Adv Inst Mat Sci, 2055 Yanan St, Changchun 130012, Jilin, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, 5625 Renmin St, Changchun 130022, Jilin, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
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Qiao, Lihong,Sun, Tingting,Zheng, Xiaohua,et al. Exploring the optimal ratio of D-glucose/L-aspartic acid for targeting carbon dots toward brain tumor cells[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2018,85:1-6.
APA Qiao, Lihong,Sun, Tingting,Zheng, Xiaohua,Zheng, Min,&Xie, Zhigang.(2018).Exploring the optimal ratio of D-glucose/L-aspartic acid for targeting carbon dots toward brain tumor cells.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,85,1-6.
MLA Qiao, Lihong,et al."Exploring the optimal ratio of D-glucose/L-aspartic acid for targeting carbon dots toward brain tumor cells".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 85(2018):1-6.
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