ICCAS OpenIR
RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin
Li, Xue1,2; Zhen, Mingming1,2; Deng, Ruijun1,2; Yu, Tong1,2; Li, Jie1,2; Zhang, Ying1,2; Zou, Toujun1; Zhou, Yue1,2; Lu, Zhigao1,2; Guan, Mirong1,2; Xu, Hui1; Shu, Chunying1,2; Wang, Chunru1,2
2018-05-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume163Pages:142-153
AbstractThe tumor vasculature with unique characteristics offers an attractive target for anti-cancer therapy. Herein, we put forward a novel antitumor therapeutic mechanism based on the gadofullerene nano crystals (GFNCs), the agent we have previously shown to efficiently disrupt tumor vasculature by size expansion with assistance of radiofrequency (RF). However, the tumor vascular disrupting mechanism of RF-assisted GFNCs treatment was not further studied. In the present work, a rapid tumor blood flow shutdown has been observed by the vascular perfusion imaging in vivo and vascular damages were evident 6 h after the RF-assisted GFNCs treatment. Importantly, a significant down-expression of tumor vascular endothelial cadherin (VE-cadherin) treated by RF-assisted GFNCs was further investigated, which caused vascular collapse, blood flow shut-down and subsequent tumor hemorrhagic necrosis. These findings set forth a systematic mechanism on the superior anti-tumor efficiency by RF-assisted GFNCs treatment. (C) 2018 The Authors. Published by Elsevier Ltd.
KeywordAntitumor Agents Gadofullerenes Radiofrequency Tumor Vascular-disruption Ve-cadherin
DOI10.1016/j.biomaterials.2018.02.028
Indexed BySCI
Language英语
WOS IDWOS:000428606700013
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/45986
Collection中国科学院化学研究所
Corresponding AuthorZhen, Mingming; Wang, Chunru
Affiliation1.Chinese Acad Sci, Inst Chem, CAS Res Educ Ctr Excellence Mol Sci, Beijing Natl Lab Mol Sci,Key Lab Mol Nanostruct &, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Xue,Zhen, Mingming,Deng, Ruijun,et al. RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin[J]. BIOMATERIALS,2018,163:142-153.
APA Li, Xue.,Zhen, Mingming.,Deng, Ruijun.,Yu, Tong.,Li, Jie.,...&Wang, Chunru.(2018).RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin.BIOMATERIALS,163,142-153.
MLA Li, Xue,et al."RF-assisted gadofullerene nanoparticles induces rapid tumor vascular disruption by down-expression of tumor vascular endothelial cadherin".BIOMATERIALS 163(2018):142-153.
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