ICCAS OpenIR
A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO
Gu, Yingchun1,2; Lin, Dayong3; Tang, Yalin1; Fei, Xuening2,3; Wang, Cuihong2; Zhang, Baolian2; Zhou, Jianguo2
2018-02-15
Source PublicationSPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
ISSN1386-1425
Volume191Pages:180-188
AbstractAs its significant role, the selective recognition of G-quadruplex with specific structures and functions is important in biological and medicinal chemistry. Carbazole derivatives have been reported as a kind of fluorescent probe with many excellent optical properties. In the present study, the fluorescence of the dye (carbazole TO) increased almost 70 fold in the presence of bcl-2 2345 G4 compared to that alone in aqueous buffer condition with almost no fluorescence and 10-30 fold than those in the presence of other DNAs. The binding study results by activity inhibition of G4/Hemin peroxidase experiment, NMR titration and molecular docking simulation showed the high affinity and selectivity to bcl-2 2345 G4 arises from its end-stacking interaction with G-quartet. It is said that a facile approach with excellent sensitive, good selectivity and quick response for bcl-2 2345 G-quadruplex was developed and may be used for antitumor recognition or antitumor agents. (C) 2017 Elsevier B.V. All rights reserved.
KeywordCarbazole To Bcl-2 2345 G-quadruplex Targeting Fluorescent Probe Light Up
DOI10.1016/j.saa.2017.10.012
Indexed BySCI
Language英语
WOS IDWOS:000418107000021
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/45224
Collection中国科学院化学研究所
Corresponding AuthorFei, Xuening
Affiliation1.Chinese Acad Sci ICCAS, Inst Chem, Beijing 100190, Peoples R China
2.Tianjin Chengjian Univ, Sch Sci, Tianjin 300384, Peoples R China
3.Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Gu, Yingchun,Lin, Dayong,Tang, Yalin,et al. A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2018,191:180-188.
APA Gu, Yingchun.,Lin, Dayong.,Tang, Yalin.,Fei, Xuening.,Wang, Cuihong.,...&Zhou, Jianguo.(2018).A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,191,180-188.
MLA Gu, Yingchun,et al."A light-up probe targeting for Bcl-2 2345 G-quadruplex DNA with carbazole TO".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 191(2018):180-188.
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