ICCAS OpenIR
Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy
Lian, Xizhen1; Huang, Yanyan2,3; Zhu, Yuanyuan2,3; Fang, Yu1; Zhao, Rui2,3; Joseph, Elizabeth1; Li, Jialuo1; Pellois, Jean-Philippe1,4; Zhou, Hong-Cai1
2018-05-14
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume57Issue:20Pages:5725-5730
AbstractProdrug activation, by exogenously administered enzymes, for cancer therapy is an approach to achieve better selectivity and less systemic toxicity than conventional chemotherapy. However, the short half-lives of the activating enzymes in the bloodstream has limited its success. Demonstrated here is that a tyrosinase-MOF nanoreactor activates the prodrug paracetamol in cancer cells in a long-lasting manner. By generating reactive oxygen species (ROS) and depleting glutathione (GSH), the product of the enzymatic conversion of paracetamol is toxic to drug-resistant cancer cells. Tyrosinase-MOF nanoreactors cause significant cell death in the presence of paracetamol for up to three days after being internalized by cells, while free enzymes totally lose activity in a few hours. Thus, enzyme-MOF nanocomposites are envisioned to be novel persistent platforms for various biomedical applications.
KeywordCancer Drug Delivery Enzymes Metal-organic Frameworks Nanoparticles
DOI10.1002/anie.201801378
Indexed BySCI
Language英语
WOS IDWOS:000431488200024
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:49[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/43284
Collection中国科学院化学研究所
Corresponding AuthorZhou, Hong-Cai
Affiliation1.Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA
2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
4.Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA
Recommended Citation
GB/T 7714
Lian, Xizhen,Huang, Yanyan,Zhu, Yuanyuan,et al. Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2018,57(20):5725-5730.
APA Lian, Xizhen.,Huang, Yanyan.,Zhu, Yuanyuan.,Fang, Yu.,Zhao, Rui.,...&Zhou, Hong-Cai.(2018).Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(20),5725-5730.
MLA Lian, Xizhen,et al."Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.20(2018):5725-5730.
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