ICCAS OpenIR
Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer
Guo, Xueling1,2; Zhuang, Qianfen1; Ji, Tianjiao3; Zhang, Yinlong3; Li, Changjian1,2; Wang, Yueqi1,2; Li, Hong1,2; Jia, Hongying1; Liu, Yang1; Du, Libo1
2018-09-01
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume195Pages:311-320
AbstractChemotherapy-based treatment for cancer has made great progress in the past decades. However, there is still a big challenge for the treatment of lung cancer. Herein, a multifunctional nanocarrier was developed through electrostatic interaction between the fluorescent gold nanocluster-conjugated chitosan and the nucleolin targeting AS1411 aptamer. Then methotrexate was loaded into the multifunctional nanocarrier through hydrophobic interaction to obtain the nanodrug carrier systems. The prepared nanodrug carrier systems have an average nanoparticle size of 200 nm with 13.8% drug loading efficiency. The drug release is pH-dependent. The in vitro results demonstrated that the nanodrug carrier systems were selectively taken up by cancer cells in a time-dependent manner and exhibited significantly enhanced anticancer activity in a model of lung cancer A549 cells. The in vivo results showed that intravenous administration of nanodrug carrier systems into BALB/c mice led to accumulation of methotrexate at the tumor site and significantly inhibited the tumor growth but without overt toxicity. The present study suggests that the prepared multifunctional nanocarrier can be used as an effective drug delivery system for anticancer drugs and exhibits great potential in clinical applications.
KeywordAnticancer Drug Delivery Nanoparticle Cell Imaging Aptamer
DOI10.1016/j.carbpol.2018.04.087
Indexed BySCI
Language英语
WOS IDWOS:000433204900036
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/42864
Collection中国科学院化学研究所
Corresponding AuthorLiu, Yang; Du, Libo
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Guo, Xueling,Zhuang, Qianfen,Ji, Tianjiao,et al. Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer[J]. CARBOHYDRATE POLYMERS,2018,195:311-320.
APA Guo, Xueling.,Zhuang, Qianfen.,Ji, Tianjiao.,Zhang, Yinlong.,Li, Changjian.,...&Du, Libo.(2018).Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer.CARBOHYDRATE POLYMERS,195,311-320.
MLA Guo, Xueling,et al."Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer".CARBOHYDRATE POLYMERS 195(2018):311-320.
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