ROS-Responsive Chalcogen-Containing Polycarbonates for Photodynamic Therapy
Yu, Li; Yang, Yue; Du, Fu-Sheng; Li, Zi-Chen
AbstractReactive oxygen species (ROS)-responsive polymers have attracted attention for their potential in photodynamic therapy. Herein, we report the ROS-responsive aliphatic poly carbonates prepared by the ring-opening polymerization (ROP) of three six-membered cyclic carbonate monomers with ethyl selenide, phenyl selenide or ethyl telluride groups. Under catalysis of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), all three monomers underwent the controlled anionic ROP, showing a feature of equilibrium polymerization due to the bulky effect of 5,5-disubstituents. With PEG macroinitiator, three series amphiphilic block copolymers were prepared. They could form spherical nanoparticles of similar to 100 nm, which were stable in neutral phosphate buffer but dissociated rapidly under triggering of H2O2. We studied the H2O2-induced oxidation profiles of selenide- or telluride-containing small molecules by H-1 NMR and revealed the factors that affect the oxidation kinetics and products. On this basis, the oxidative degradation mechanism of the copolymer nanoparticles has been clarified. Under the same oxidative condition, the telluride-containing nanoparticle degraded with the fastest rate while the phenyl selenide-based one degraded most slowly. These ROS-responsive nanoparticles could load photosensitizer chlorin e6 (Ce6) and anticancer drug doxorubicin (DOX). Under red light irradiation, Ce6-sensitized production of O-1(2) that triggered the degradation of nanoparticles, resulting in an accelerated payload release. In vitro cytotoxicity assays demonstrate that the nanoparticles coloaded with DOX and Ce6 exhibited a synergistic cell-killing effect to MCF-7 cells, representing a novel responsive nanoplatform for PDT and/or chemotherapy.
Indexed BySCI
WOS IDWOS:000435226200041
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Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorDu, Fu-Sheng; Li, Zi-Chen
AffiliationPeking Univ, Coll Chem & Mol Engn, Dept Polymer Sci & Engn, BNLMS,Key Lab Polymer Chem & Phys,Minist Educ, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Yu, Li,Yang, Yue,Du, Fu-Sheng,et al. ROS-Responsive Chalcogen-Containing Polycarbonates for Photodynamic Therapy[J]. BIOMACROMOLECULES,2018,19(6):2182-2193.
APA Yu, Li,Yang, Yue,Du, Fu-Sheng,&Li, Zi-Chen.(2018).ROS-Responsive Chalcogen-Containing Polycarbonates for Photodynamic Therapy.BIOMACROMOLECULES,19(6),2182-2193.
MLA Yu, Li,et al."ROS-Responsive Chalcogen-Containing Polycarbonates for Photodynamic Therapy".BIOMACROMOLECULES 19.6(2018):2182-2193.
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