ICCAS OpenIR  > 分子动态与稳态结构实验室
A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode
Li, Changjian1,2; Wang, Yueqi1,2; Huang, Saipeng3; Zhang, Xiaojie1; Kang, Xiaoxuan1; Sun, Yanchi4; Hu, Ziyuan4; Han, Lu4; Du, Libo1; Liu, Yang1
2018-10-01
Source PublicationTALANTA
ISSN0039-9140
Volume188Pages:316-324
AbstractLysosome fluorescent imaging has been widely used in the field of biological staining and diagnostics, which plays a key role in understanding intracellular metabolism and various physiological processes. However, for most currently used small-molecule lysotrackers, the photostability is often unsatisfactory when used for long-term and real-time visualization of lysosomal dynamics. Herein, we reported a new lysosome-targetable photostable fluorescent probe (i.e. MPL-NPA), and results showed that MPL-NAP possesses superior photostability, appreciable tolerance to pH change, low cytotoxicity and high lysosome targeting ability. These findings confirm that MPL-NAP is a well-suited imaging agent for targeting lysosome and enables long-term and real-time monitor of lysosome morphological changes under physiological processes.
KeywordLysosome Imaging Photostability Long-term Imagining Fluorescence 1 8-naphthalimides
DOI10.1016/j.talanta.2018.06.001
Indexed BySCI
Language英语
WOS IDWOS:000440958700042
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/41945
Collection分子动态与稳态结构实验室
Corresponding AuthorDu, Libo; Liu, Yang
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Northwest Univ, Sch Chem Engn, Xian 710075, Shaanxi, Peoples R China
4.Beijing Inst Graph Commun, Beijing Engn Res Ctr Printed Elect, Beijing 102600, Peoples R China
Recommended Citation
GB/T 7714
Li, Changjian,Wang, Yueqi,Huang, Saipeng,et al. A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode[J]. TALANTA,2018,188:316-324.
APA Li, Changjian.,Wang, Yueqi.,Huang, Saipeng.,Zhang, Xiaojie.,Kang, Xiaoxuan.,...&Liu, Yang.(2018).A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode.TALANTA,188,316-324.
MLA Li, Changjian,et al."A photostable fluorescent probe for long-time imagining of lysosome in cell and nematode".TALANTA 188(2018):316-324.
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