ICCAS OpenIR  > 高分子物理与化学实验室
Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells
Yu, Ting-Ting1; Cui, Fu-Zhai2; Meng, Qing-Yuan2; Wang, Juan3,4; Wu, De-Cheng3,4; Zhang, Jin5; Kou, Xiao-Xing1; Yang, Rui-Li1; Liu, Yan1; Zhang, Yu Shrike5; Yang, Fei3,4; Zhou, Yan-Heng1
2017-06-01
Source PublicationACS BIOMATERIALS SCIENCE & ENGINEERING
Volume3Issue:6Pages:1119-1128
AbstractThe complex interaction between extracellular matrix and cells makes the design of materials for dental regeneration challenging. Chemical composition is an important characteristic of biomaterial surfaces, which plays an essential role in modulating the adhesion and function of cells. The effect of different chemical groups on directing the fate of human dental pulp stem cells (hDPSCs) was thus explored in our study. A range of self-assembled monolayers (SAMs) with amino (-NH2), hydroxyl (-OH), carboxyl (-COOH), and methyl (-CH3) modifications were prepared. Proliferation, morphology, adhesion, and differentiation of hDPSCs were then analyzed to demonstrate the effects of surface chemical groups. The results showed that hDPSCs attached to the -NH2 surface displayed a highly branched osteocytelike morphology with improved cell adhesion and proliferation abilities. Moreover, hDPSCs cultured on the -NH2 surface also tended to obtain an increased osteo/odontogenesis differentiation potential. However, the hDPSCs on the -COOH, -OH, and -CH3 surfaces preferred to maintain the mesenchymal stem cell-like phenotype. In summary, this study indicated the influence of chemical groups on hDPSCs in vitro and demonstrated that -NH2 might be a promising surface modification strategy to achieve improved biocompatibility, osteoconductivity/osteoinductivity, and osseointegration of dental implants, potentially facilitating dental tissue regeneration.
KeywordSurface Chemistry Dental Pulp Stem Cells Adhesion Cell Fate Self-assembled Monolayer
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/38921
Collection高分子物理与化学实验室
Affiliation1.Peking Univ, Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Dept Orthodont, Beijing 100081, Peoples R China
2.Tsinghua Univ, Sch Mat Sci & Engn, Beijing 100084, Peoples R China
3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Engn Med, Cambridge, MA 02139 USA
Recommended Citation
GB/T 7714
Yu, Ting-Ting,Cui, Fu-Zhai,Meng, Qing-Yuan,et al. Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2017,3(6):1119-1128.
APA Yu, Ting-Ting.,Cui, Fu-Zhai.,Meng, Qing-Yuan.,Wang, Juan.,Wu, De-Cheng.,...&Zhou, Yan-Heng.(2017).Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells.ACS BIOMATERIALS SCIENCE & ENGINEERING,3(6),1119-1128.
MLA Yu, Ting-Ting,et al."Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells".ACS BIOMATERIALS SCIENCE & ENGINEERING 3.6(2017):1119-1128.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yu, Ting-Ting]'s Articles
[Cui, Fu-Zhai]'s Articles
[Meng, Qing-Yuan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yu, Ting-Ting]'s Articles
[Cui, Fu-Zhai]'s Articles
[Meng, Qing-Yuan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yu, Ting-Ting]'s Articles
[Cui, Fu-Zhai]'s Articles
[Meng, Qing-Yuan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.